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Background <p>Ultra-high dose rate (FLASH) therapy has attracted attention for its potential to effectively target tumors while preserving healthy tissues. Although the biological effects of FLASH therapy have been well-documented with electrons, photons, and protons, data regarding carbon-ions are limited. This study aimed to investigate the biological effects of carbon-ions on the intestines of mice to determine whether carbon-ions exhibit the FLASH effect. Simultaneously, we aimed to identify the parameters influencing its occurrence.</p> Materials and methods <p>Partial abdominal irradiation was performed on C3H/He mice using 290&#xa0;MeV/u FLASH and conventional dose rate (CONV) carbon-ions under both low and high linear energy transfer (LET). The evaluation included the 30-day survival rate, body weight changes, and stool pellet alterations within 14 days after irradiation. Furthermore, we assessed the number of regenerating crypts 3.5 days after irradiation.</p> Results <p>Under low-LET, FLASH and CONV irradiation exhibited comparable sparing effects on normal intestinal tissues. However, FLASH significantly improved the survival rate of mice under high-LET, when the dose rate exceeded 100&#xa0;Gy/s. The number of regenerating crypts 3.5 days after irradiation was 1.5 times higher in the FLASH group than in the CONV group.</p> Conclusions <p>The results indicate that carbon-ion FLASH exhibits the FLASH effect at high-LET with dose rate and LET identified as critical parameters influencing the FLASH effect.</p>

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Partial abdominal carbon-ion FLASH irradiation spares lethality compared to conventional irradiation: impact of LET and dose rate

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月28日

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  • Wenteng Cao,
  • Yukari Yoshida,
  • Hiromu Suda,
  • Shunsuke Inagaki,
  • Naoto Urabe,
  • Masao Nakao,
  • Ken Yusa,
  • Xiangdi Meng,
  • Mutsumi Tashiro,
  • Akihisa Takahashi,
  • Tatsuya Ohno

摘要

Background

Ultra-high dose rate (FLASH) therapy has attracted attention for its potential to effectively target tumors while preserving healthy tissues. Although the biological effects of FLASH therapy have been well-documented with electrons, photons, and protons, data regarding carbon-ions are limited. This study aimed to investigate the biological effects of carbon-ions on the intestines of mice to determine whether carbon-ions exhibit the FLASH effect. Simultaneously, we aimed to identify the parameters influencing its occurrence.

Materials and methods

Partial abdominal irradiation was performed on C3H/He mice using 290 MeV/u FLASH and conventional dose rate (CONV) carbon-ions under both low and high linear energy transfer (LET). The evaluation included the 30-day survival rate, body weight changes, and stool pellet alterations within 14 days after irradiation. Furthermore, we assessed the number of regenerating crypts 3.5 days after irradiation.

Results

Under low-LET, FLASH and CONV irradiation exhibited comparable sparing effects on normal intestinal tissues. However, FLASH significantly improved the survival rate of mice under high-LET, when the dose rate exceeded 100 Gy/s. The number of regenerating crypts 3.5 days after irradiation was 1.5 times higher in the FLASH group than in the CONV group.

Conclusions

The results indicate that carbon-ion FLASH exhibits the FLASH effect at high-LET with dose rate and LET identified as critical parameters influencing the FLASH effect.