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Objective <p>To examine patterns of abstinence from nicotine vaping and cannabis use among adolescent and young adult (YA) e-cigarette users in two text message vaping cessation trials.</p> Methods <p>Among adolescents with complete 7-month data (<i>n</i> = 1,016) at baseline, 25.4% were <i>Exclusive E-cigarette Users</i> (no past 30-day cannabis use) and 74.6% were <i>Dual Users</i> (past 30-day cannabis use). Among YAs with complete 7-month data (<i>n</i> = 1,829), 40.8% were <i>Exclusive E-cigarette Users</i> and 59.2% were <i>Dual Users</i> at baseline. Primary analyses examined the proportion of participants who were <i>Dual Abstinent</i> at 7-months by treatment arm differences. We also examined for interaction effects between baseline product use and vaping status at 7 months on cannabis use outcomes.</p> Results <p>At 7-months, adolescent categories of use were: <i>Dual Abstinent</i>, 31.7% (95% CI: 28.8, 34.6); <i>Exclusive E-cigarette Users</i>, 18.2% (95% CI: 15.9, 20.7); <i>Exclusive Cannabis Users</i>, 15.1% (95% CI: 12.9, 17.4); <i>Dual Users</i>, 35.0% (95% CI: 32.1, 38.1). Among YAs: <i>Dual Abstinent</i>, 15.6% (95% CI: 13.9, 17.3); <i>Exclusive E-cigarette Users</i>, 29.4% (95% CI: 27.3, 31.6); <i>Exclusive Cannabis Users</i>, 12.8% (95% CI: 11.3, 14.5); <i>Dual Users</i>, 42.2% (95% CI: 39.9, 44.5). Intervention outperformed Control in promoting rates of <i>Dual Abstinence</i> among adolescents (38.5% vs. 25.0%, <i>p</i> &lt; 0.0001) and YAs (17.9% vs. 13.3%, <i>p</i> = 0.007). A higher proportion of <i>Exclusive E-cigarette Users</i> compared to <i>Dual Users</i> were <i>Dual Abstinent</i> at follow-up (adolescents: 37.6% vs. 29.7%, <i>p</i> = 0.019; YAs: 25.8% vs. 8.5%, <i>p</i> &lt; 0.001).</p> Conclusion <p>A text message nicotine vaping cessation intervention promoted dual abstinence from e-cigarettes and cannabis among adolescents and YAs. Dual abstinence rates were higher among exclusive vapers than dual users, signaling the need to optimize cessation programs for dual users.</p> Trial Registration <p>Studies included were registered on ClinicalTrials.gov (NCT04251273, registered on January 31, 2020; NCT04919590, registered on June 9, 2021)</p>

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Dual abstinence from nicotine vaping and cannabis use among young people: secondary analyses from two U.S.-based randomized controlled trials of vaping cessation

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月3日

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  • Amanda L. Graham,
  • Sarah Cha,
  • Elizabeth K. Do,
  • Megan A. Jacobs,
  • Giselle Edwards,
  • George D. Papandonatos

摘要

Objective

To examine patterns of abstinence from nicotine vaping and cannabis use among adolescent and young adult (YA) e-cigarette users in two text message vaping cessation trials.

Methods

Among adolescents with complete 7-month data (n = 1,016) at baseline, 25.4% were Exclusive E-cigarette Users (no past 30-day cannabis use) and 74.6% were Dual Users (past 30-day cannabis use). Among YAs with complete 7-month data (n = 1,829), 40.8% were Exclusive E-cigarette Users and 59.2% were Dual Users at baseline. Primary analyses examined the proportion of participants who were Dual Abstinent at 7-months by treatment arm differences. We also examined for interaction effects between baseline product use and vaping status at 7 months on cannabis use outcomes.

Results

At 7-months, adolescent categories of use were: Dual Abstinent, 31.7% (95% CI: 28.8, 34.6); Exclusive E-cigarette Users, 18.2% (95% CI: 15.9, 20.7); Exclusive Cannabis Users, 15.1% (95% CI: 12.9, 17.4); Dual Users, 35.0% (95% CI: 32.1, 38.1). Among YAs: Dual Abstinent, 15.6% (95% CI: 13.9, 17.3); Exclusive E-cigarette Users, 29.4% (95% CI: 27.3, 31.6); Exclusive Cannabis Users, 12.8% (95% CI: 11.3, 14.5); Dual Users, 42.2% (95% CI: 39.9, 44.5). Intervention outperformed Control in promoting rates of Dual Abstinence among adolescents (38.5% vs. 25.0%, p < 0.0001) and YAs (17.9% vs. 13.3%, p = 0.007). A higher proportion of Exclusive E-cigarette Users compared to Dual Users were Dual Abstinent at follow-up (adolescents: 37.6% vs. 29.7%, p = 0.019; YAs: 25.8% vs. 8.5%, p < 0.001).

Conclusion

A text message nicotine vaping cessation intervention promoted dual abstinence from e-cigarettes and cannabis among adolescents and YAs. Dual abstinence rates were higher among exclusive vapers than dual users, signaling the need to optimize cessation programs for dual users.

Trial Registration

Studies included were registered on ClinicalTrials.gov (NCT04251273, registered on January 31, 2020; NCT04919590, registered on June 9, 2021)