Scholarlink

<p>Carcinogenic factors facilitate cell carcinogenesis and the progression of cancer. In contrast, tumor suppressor factors inhibit abnormal cell proliferation and cancer development. Accumulating evidence indicates that long non-coding RNAs (lncRNAs) can either suppress or promote cancer initiation and progression. LINC01140, a recently identified lncRNA, exhibits abnormal expression in cancerous tissues. Downstream target genes can be regulated, directly or indirectly, via miRNAs (miR-452-5p, miR-139-5p, miR-140-5p, miR-33a, miR-4742-5p, miR-200b-3p, and miR-452-5p), functioning as either oncogenes or tumor suppressors and contributing to cancer progression. Dysregulated LINC01140 expression shows significant correlations with patient survival, diagnosis, and cancer stage. Consequently, this review aims to examine the expression patterns, functional roles, and clinical significance of LINC01140 across pan-cancer, highlighting it as a potential therapeutic target for cancer treatment.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The roles and clinical significance of LINC01140 in human cancers in the real world

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月5日

查看全文
  • Wen-Jing Men,
  • Xiang-Sheng Wen

摘要

Carcinogenic factors facilitate cell carcinogenesis and the progression of cancer. In contrast, tumor suppressor factors inhibit abnormal cell proliferation and cancer development. Accumulating evidence indicates that long non-coding RNAs (lncRNAs) can either suppress or promote cancer initiation and progression. LINC01140, a recently identified lncRNA, exhibits abnormal expression in cancerous tissues. Downstream target genes can be regulated, directly or indirectly, via miRNAs (miR-452-5p, miR-139-5p, miR-140-5p, miR-33a, miR-4742-5p, miR-200b-3p, and miR-452-5p), functioning as either oncogenes or tumor suppressors and contributing to cancer progression. Dysregulated LINC01140 expression shows significant correlations with patient survival, diagnosis, and cancer stage. Consequently, this review aims to examine the expression patterns, functional roles, and clinical significance of LINC01140 across pan-cancer, highlighting it as a potential therapeutic target for cancer treatment.