<p>Seronegative spondyloarthropathy (SpA) and Takayasu’s arteritis (TA) are distinct chronic inflammatory conditions with autoimmune characteristics. While both conditions are relatively common, their concurrent occurrence is rare. This case report presents an individual diagnosed with both SpA and TA, detailing the clinical presentation, disease course, and therapeutic interventions. A review of relevant literature is also included to enhance clinical awareness of this uncommon combination. For that patients with SpA who exhibit elevated inflammatory markers, intermittent low-grade fever, fatigue, or inadequate response to standard therapies, it’s better to undergo evaluation for the potential presence of TA. Early identification of TA in such cases may help mitigate the risks of misdiagnosis or delayed diagnosis.</p>