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Background <p>Concomitant gastric cancer and neuroendocrine tumours in the stomach are very rare, and their clinical characteristics, pathogenesis and treatment principles remain poorly understood.</p> Case presentation <p>We present three cases of concomitant gastric cancer and neuroendocrine tumours in the stomach, all of which were pathologically diagnosed through endoscopy and biopsy. One patient received total gastrectomy, while the other two patients underwent endoscopic resection. Moreover, the diagnostic characteristics and treatment of synchronous gastric cancer and neuroendocrine tumours are summarized and analysed in combination with a study of 8 cases.</p> Conclusions <p>G1 NET may be more likely to be concomitant with gastric cancer. Endoscopic resection is the preferred treatment for patients with synchronous early gastric cancer and NETs.</p>

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Concomitant gastric cancer and neuroendocrine tumours in the stomach: a rare case series of 3 patients and a literature review

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  • 发表日期：

    2025年8月29日

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  • Luyu Liu,
  • Weilu Ding,
  • Zhenzhen Wang,
  • Gongning Wang,
  • Limian Er

摘要

Background

Concomitant gastric cancer and neuroendocrine tumours in the stomach are very rare, and their clinical characteristics, pathogenesis and treatment principles remain poorly understood.

Case presentation

We present three cases of concomitant gastric cancer and neuroendocrine tumours in the stomach, all of which were pathologically diagnosed through endoscopy and biopsy. One patient received total gastrectomy, while the other two patients underwent endoscopic resection. Moreover, the diagnostic characteristics and treatment of synchronous gastric cancer and neuroendocrine tumours are summarized and analysed in combination with a study of 8 cases.

Conclusions

G1 NET may be more likely to be concomitant with gastric cancer. Endoscopic resection is the preferred treatment for patients with synchronous early gastric cancer and NETs.