Scholarlink

Background <p>Neonatal hypoxic–ischemic encephalopathy (HIE) is a leading cause of neurodevelopmental disability. Low-level laser therapy (LLLT), or photobiomodulation, has shown neuroprotective potential, but its long-term effects and region-specific responses remain poorly defined.</p> Methods <p>Neonatal rats subjected to hypoxic–ischemic brain damage (HIBD) received transcranial 810-nm LLLT (24 mW/cm², 10&#xa0;min/session, twice daily for three days). Histological, immunofluorescence, and Western blot analyses assessed neuronal integrity, glial activation, and signaling pathway changes. Sensorimotor function was evaluated by grip traction and open-field tests, and spatial learning and memory were assessed using the Morris water maze (MWM) at long-term follow-up.</p> Results <p>LLLT reduced neuronal loss and glial reactivity and was associated with increased Nrf2/HO-1 and Akt signaling at early time points. Behaviorally, LLLT improved motor and cognitive performance, with benefits persisting up to 20 weeks post-injury.</p> Conclusion <p>Early LLLT is associated with sustained functional recovery after neonatal hypoxic–ischemic injury. These effects may involve early modulation of antioxidant and pro-survival signaling pathways, although the mechanisms underlying long-term outcomes require further investigation.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Low-level laser therapy enhances neuroprotection and functional recovery after neonatal hypoxic–ischemic injury via potential activation of Nrf2/HO-1 and Akt pathways

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年4月28日

查看全文
  • Ping Liu,
  • Sunxin Zhang,
  • Huan Wang,
  • Zhili Li

摘要

Background

Neonatal hypoxic–ischemic encephalopathy (HIE) is a leading cause of neurodevelopmental disability. Low-level laser therapy (LLLT), or photobiomodulation, has shown neuroprotective potential, but its long-term effects and region-specific responses remain poorly defined.

Methods

Neonatal rats subjected to hypoxic–ischemic brain damage (HIBD) received transcranial 810-nm LLLT (24 mW/cm², 10 min/session, twice daily for three days). Histological, immunofluorescence, and Western blot analyses assessed neuronal integrity, glial activation, and signaling pathway changes. Sensorimotor function was evaluated by grip traction and open-field tests, and spatial learning and memory were assessed using the Morris water maze (MWM) at long-term follow-up.

Results

LLLT reduced neuronal loss and glial reactivity and was associated with increased Nrf2/HO-1 and Akt signaling at early time points. Behaviorally, LLLT improved motor and cognitive performance, with benefits persisting up to 20 weeks post-injury.

Conclusion

Early LLLT is associated with sustained functional recovery after neonatal hypoxic–ischemic injury. These effects may involve early modulation of antioxidant and pro-survival signaling pathways, although the mechanisms underlying long-term outcomes require further investigation.