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Background <p>Theoretical hypotheses suggest differing oxidative stress levels in mood disorders. We evaluated eight oxidative stress-related biochemical markers for further verification in first-onset patients with bipolar disorder (BD) or major depressive disorder (MDD).</p> Methods <p>We extracted 224 first-onset patients (BD = 93 and MDD = 131) from the overall sample database of 4647 candidates. And we analyzed eight parameters: direct bilirubin (DBIL), indirect bilirubin (IBIL), uric acid (UA), lactate dehydrogenase (LDH), thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), prealbumin, and progesterone.The above parameters enter the hierarchical multiple linear regression model for analysis.</p> Results <p>When compared to MDD, the BD group showed decreased prealbumin and elevated UA, LDH, and FT3 in males while decreased prealbumin and DBIL and elevated IDBIL, LDH, FT3 and progesterone in females (<i>p</i>’s &lt; 0.05). The model effectively differentiated between BD and MDD, achieving AUCs of 0.894 for men and 0.897 for women.</p> Conclusion <p>This result elucidates the validity of these biomarkers for identifying first-episode patients with BD or MDD. The discrimination was satisfactory, with good diagnostic accuracy for both gender subgroups.</p>

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Discrimination of first-onset patients with bipolar disorder or major depressive disorder using screened biochemical parameters

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月14日

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  • Yuncheng Zhu,
  • Sheng Li,
  • Ju Gao,
  • Fang Wang,
  • Ni Zhou,
  • Chuangxin Wu,
  • Xiaojia Huang,
  • Ningning Li,
  • Xiaohui Wu,
  • Hongmei Liu,
  • Lu Yang,
  • Xiaoyun Guo,
  • Zuowei Wang,
  • Yiru Fang

摘要

Background

Theoretical hypotheses suggest differing oxidative stress levels in mood disorders. We evaluated eight oxidative stress-related biochemical markers for further verification in first-onset patients with bipolar disorder (BD) or major depressive disorder (MDD).

Methods

We extracted 224 first-onset patients (BD = 93 and MDD = 131) from the overall sample database of 4647 candidates. And we analyzed eight parameters: direct bilirubin (DBIL), indirect bilirubin (IBIL), uric acid (UA), lactate dehydrogenase (LDH), thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), prealbumin, and progesterone.The above parameters enter the hierarchical multiple linear regression model for analysis.

Results

When compared to MDD, the BD group showed decreased prealbumin and elevated UA, LDH, and FT3 in males while decreased prealbumin and DBIL and elevated IDBIL, LDH, FT3 and progesterone in females (p’s < 0.05). The model effectively differentiated between BD and MDD, achieving AUCs of 0.894 for men and 0.897 for women.

Conclusion

This result elucidates the validity of these biomarkers for identifying first-episode patients with BD or MDD. The discrimination was satisfactory, with good diagnostic accuracy for both gender subgroups.