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Background and aim <p>L-carnitine plays a central role in fatty acid metabolism and has been proposed as a potential strategy for improving lipid regulation. However, evidence from clinical trials remains inconsistent, and female-specific data are scarce. This systematic review and meta-analysis aimed to evaluate the effects of L-carnitine supplementation on lipid profiles specifically in women with overweight or obesity.</p> Methods <p>A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted in accordance with PRISMA guidelines. Eligible studies enrolled women with BMI ≥ 25&#xa0;kg/m² and compared L-carnitine supplementation with placebo or no intervention. Pooled weighted mean differences (WMDs) with 95% confidence intervals (CIs) were calculated using a random-effects model.</p> Results <p>Ten RCTs were included. L-carnitine supplementation significantly reduced TG (WMD: − 8.01&#xa0;mg/dL; 95%CI: − 15.21 to − 0.81), TC (WMD: − 7.85&#xa0;mg/dL; 95%CI: − 14.54 to − 1.16), and LDL-C (WMD: − 5.59&#xa0;mg/dL;95%CI: − 10.02 to − 1.16). No significant overall effect was found for HDL-C (WMD:1.09&#xa0;mg/dL;95%CI: − 1.79 to 3.99). Subgroup analyses indicated stronger effects at higher doses, shorter intervention durations, and in participants with elevated baseline lipid levels.</p> Conclusion <p>L-carnitine supplementation provides significant improvements in TG, TC, and LDL-C among overweight and obese women, although HDL-C responses remain inconsistent. These findings suggest a potential adjunctive role for L-carnitine in cardiometabolic risk management.</p>

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Impact of L-carnitine supplementation on lipid profile parameters in overweight and obese women: a systematic review and meta-analysis of randomized controlled trials

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月22日

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  • Yongmei Yu,
  • Dongping Xu,
  • Siyi Shang,
  • Yuanxia Liu,
  • Zhengxian Qian

摘要

Background and aim

L-carnitine plays a central role in fatty acid metabolism and has been proposed as a potential strategy for improving lipid regulation. However, evidence from clinical trials remains inconsistent, and female-specific data are scarce. This systematic review and meta-analysis aimed to evaluate the effects of L-carnitine supplementation on lipid profiles specifically in women with overweight or obesity.

Methods

A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted in accordance with PRISMA guidelines. Eligible studies enrolled women with BMI ≥ 25 kg/m² and compared L-carnitine supplementation with placebo or no intervention. Pooled weighted mean differences (WMDs) with 95% confidence intervals (CIs) were calculated using a random-effects model.

Results

Ten RCTs were included. L-carnitine supplementation significantly reduced TG (WMD: − 8.01 mg/dL; 95%CI: − 15.21 to − 0.81), TC (WMD: − 7.85 mg/dL; 95%CI: − 14.54 to − 1.16), and LDL-C (WMD: − 5.59 mg/dL;95%CI: − 10.02 to − 1.16). No significant overall effect was found for HDL-C (WMD:1.09 mg/dL;95%CI: − 1.79 to 3.99). Subgroup analyses indicated stronger effects at higher doses, shorter intervention durations, and in participants with elevated baseline lipid levels.

Conclusion

L-carnitine supplementation provides significant improvements in TG, TC, and LDL-C among overweight and obese women, although HDL-C responses remain inconsistent. These findings suggest a potential adjunctive role for L-carnitine in cardiometabolic risk management.