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Background <p><i>Helicobacter pylori</i> infection and oxidative stress are most common factors for development of gastric ulcers which is consider to be a most common gastrointestinal disorder. The main objective of this research was to evaluate the effects of avocado seeds aqueous extract as an adjunct to conventional ulcer treatment.</p> Methods <p>A randomized controlled trial was conducted with the participation of 99 patients diagnosed with gastric ulcers. Participants were randomly divided to a control group receiving standard medication and interventional group receiving the same treatment with avocado seeds aqueous extract. Screening and follow-up assessments assessment was performed by barium meal tests, radiological imaging, and serological markers, including <i>H. pylori</i> IgG and IgM (ELISA).</p> Results <p>Patients in the intervention group showed significant improvements in ulcer morphology and a marked reduction in <i>H. pylori</i> IgG and IgM levels compared with the control group (<i>p</i> &lt; 0.05). Radiological findings also confirmed better mucosal healing in the supplemented group after 12 weeks of intervention.</p> Conclusions <p>Intervention group with avocado seeds aqueous extract showed a positive effect combined with conventional treatment, suggesting its potential as a natural adjunct therapy in management of gastric ulcers.</p>

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Characterization of avocado seeds aqueous extract and its therapeutic effects on gastric ulcer

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月16日

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  • Aroosa Sultan,
  • Muhammad Nadeem Akhtar,
  • Anees Ahmed Khalil,
  • Faiza Jameel,
  • Suhas Ballal,
  • Abhayveer Singh,
  • Rajashree Panigrahi,
  • Abhishek Sharma,
  • Huda Ateeq,
  • Areesha Ahmed,
  • Fakhar Islam,
  • Muhammad Afzaal,
  • Catherine Tamale Ndagire

摘要

Background

Helicobacter pylori infection and oxidative stress are most common factors for development of gastric ulcers which is consider to be a most common gastrointestinal disorder. The main objective of this research was to evaluate the effects of avocado seeds aqueous extract as an adjunct to conventional ulcer treatment.

Methods

A randomized controlled trial was conducted with the participation of 99 patients diagnosed with gastric ulcers. Participants were randomly divided to a control group receiving standard medication and interventional group receiving the same treatment with avocado seeds aqueous extract. Screening and follow-up assessments assessment was performed by barium meal tests, radiological imaging, and serological markers, including H. pylori IgG and IgM (ELISA).

Results

Patients in the intervention group showed significant improvements in ulcer morphology and a marked reduction in H. pylori IgG and IgM levels compared with the control group (p < 0.05). Radiological findings also confirmed better mucosal healing in the supplemented group after 12 weeks of intervention.

Conclusions

Intervention group with avocado seeds aqueous extract showed a positive effect combined with conventional treatment, suggesting its potential as a natural adjunct therapy in management of gastric ulcers.