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Background <p>The association of sugar sweetened beverages (SSBs) and coronary artery disease (CAD) has not been well-established in Asians, where SSBs are the leading ultra-processed food product.</p> Objective <p>We aim to examine the association between SSBs and premature CAD (PCAD) in Iranian adults.</p> Design <p>Case-control.</p> Participants <p>A multi-centric study of Iranians including 2006 PCAD and 1131 healthy individuals as control group.</p> Main outcome measures <p>Dietary intakes were assessed using a validated food frequency questionnaire (FFQ). SSBs consist of artificial juice and sugar -sweetened drinks. The PCAD was determined based on the results of angiography and the occlusion percent of vessels.</p> Statistical analysis <p>The odds of PCAD across the quartiles of SSBs were assessed by binary logistic regression.</p> Results <p>The mean (SD) age of participants and SSB consumption was 51.5 years and 46.9&#xa0;g/d, respectively. In the fully-adjusted model, compared with participants in the first quartile, those in the fourth quartile had higher risk of PCAD (OR = 1.50, 95% CI: 1.12, 2.00; P trend = 0.044). Consistently, SSB consumption was directly associated with the severity of PCAD. The higher SSB consumption, the greater risk for the severe PCAD (OR Q4 vs. Q1 = 1.34, 95% CI: 1.06, 1.68; <i>P</i> &lt; 0.001).</p> Conclusion <p>This study demonstrated that higher consumption of SSB might be associated with higher risk of PCAD. However, more prospective cohort studies are necessary to confirm this association.</p>

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Sugar-sweetened beverage consumption and risk of premature coronary artery disease in a multi-ethnic Iranian case–control study

  • 期刊论文

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  • 发表日期：

    2025年8月27日

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  • Noushin Mohammadifard,
  • Negar Ostadsharif,
  • Ghazaleh Bahrami,
  • Motahare Bateni,
  • Ehsan Zarepur,
  • Fatemeh Nouri,
  • Fereidoon Nouhi,
  • Nahid Azdaki,
  • Nahid Salehi,
  • Masoud Lotfizadeh,
  • Samad Ghaffari,
  • Arsalan Salari,
  • Mostafa Dehghani,
  • Mostafa Cheraghi,
  • Ahmadreza Assareh,
  • Hassan Alikhasi,
  • Fahimeh Haghighatdoost,
  • Nizal Sarrafzadegan

摘要

Background

The association of sugar sweetened beverages (SSBs) and coronary artery disease (CAD) has not been well-established in Asians, where SSBs are the leading ultra-processed food product.

Objective

We aim to examine the association between SSBs and premature CAD (PCAD) in Iranian adults.

Design

Case-control.

Participants

A multi-centric study of Iranians including 2006 PCAD and 1131 healthy individuals as control group.

Main outcome measures

Dietary intakes were assessed using a validated food frequency questionnaire (FFQ). SSBs consist of artificial juice and sugar -sweetened drinks. The PCAD was determined based on the results of angiography and the occlusion percent of vessels.

Statistical analysis

The odds of PCAD across the quartiles of SSBs were assessed by binary logistic regression.

Results

The mean (SD) age of participants and SSB consumption was 51.5 years and 46.9 g/d, respectively. In the fully-adjusted model, compared with participants in the first quartile, those in the fourth quartile had higher risk of PCAD (OR = 1.50, 95% CI: 1.12, 2.00; P trend = 0.044). Consistently, SSB consumption was directly associated with the severity of PCAD. The higher SSB consumption, the greater risk for the severe PCAD (OR Q4 vs. Q1 = 1.34, 95% CI: 1.06, 1.68; P < 0.001).

Conclusion

This study demonstrated that higher consumption of SSB might be associated with higher risk of PCAD. However, more prospective cohort studies are necessary to confirm this association.