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Objective <p>Our research aimed to investigate the relationship between the monocyte-to-high-density lipoprotein-cholesterol ratio (MHR) and the risk of severe abdominal aortic calcification (SAAC).</p> Methods <p>We conducted a cross-sectional study using data from the National Health and Nutrition Examination Survey (NHANES) 2013–2014. We further performed multivariable logistic regression analysis, restricted cubic spline (RCS) plots, and subgroup analysis to study the relationship between the MHR and the risk of SAAC.</p> Results <p>A total of 3017 participants were included in this study. After complete adjustment for potential confounders, the incidence of SAAC increased with the higher quartile of MHR (<i>P</i> &lt;0.001). According to the RCS plot, a positive non-linear was the relationship between the MHR and SAAC risk, and the incidence of SAAC increased with the increase of MHR.</p> Conclusion <p>There was a positive non-linear correlation between the MHR and SAAC in US adults. Our findings imply that close monitoring and adequate control of the MHR has the potential to improve SAAC prevention in the general population.</p>

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Association of monocyte-to-high-density lipoprotein-cholesterol ratio level with risk of severe abdominal aortic calcification: a large cross-sectional study based on NHANES

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月30日

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  • Zhihao Zhao,
  • Diya Qi,
  • Fengyun Zhang,
  • Yi Liang,
  • Yu Yang,
  • Ying Gao

摘要

Objective

Our research aimed to investigate the relationship between the monocyte-to-high-density lipoprotein-cholesterol ratio (MHR) and the risk of severe abdominal aortic calcification (SAAC).

Methods

We conducted a cross-sectional study using data from the National Health and Nutrition Examination Survey (NHANES) 2013–2014. We further performed multivariable logistic regression analysis, restricted cubic spline (RCS) plots, and subgroup analysis to study the relationship between the MHR and the risk of SAAC.

Results

A total of 3017 participants were included in this study. After complete adjustment for potential confounders, the incidence of SAAC increased with the higher quartile of MHR (P <0.001). According to the RCS plot, a positive non-linear was the relationship between the MHR and SAAC risk, and the incidence of SAAC increased with the increase of MHR.

Conclusion

There was a positive non-linear correlation between the MHR and SAAC in US adults. Our findings imply that close monitoring and adequate control of the MHR has the potential to improve SAAC prevention in the general population.