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<p>This comment discusses the critical public health challenge of hepatitis E in pregnancy and highlights the significant safety evidence gap for the HEV239 vaccine in this vulnerable group. Focusing on a landmark study from South Sudan by Nesbitt RC et al., we provide a critical appraisal of its findings, integrate them with prior evidence from clinical trials and animal studies, and discuss implications for vaccination policy in outbreak settings, particularly in fragile and conflict-affected contexts. The comment concludes that vaccination during pregnancy shows no detected increased risk of fetal loss, providing crucial real-world data to inform life-saving vaccination policies, while acknowledging remaining uncertainties.</p>

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Safety of hepatitis E vaccine in pregnancy

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月25日

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  • Fan Zhang,
  • Guang Yang,
  • Yuting Chen,
  • Dongjuan Chen,
  • Zuliang Shi,
  • Jianbo Xia,
  • Ling Wang

摘要

This comment discusses the critical public health challenge of hepatitis E in pregnancy and highlights the significant safety evidence gap for the HEV239 vaccine in this vulnerable group. Focusing on a landmark study from South Sudan by Nesbitt RC et al., we provide a critical appraisal of its findings, integrate them with prior evidence from clinical trials and animal studies, and discuss implications for vaccination policy in outbreak settings, particularly in fragile and conflict-affected contexts. The comment concludes that vaccination during pregnancy shows no detected increased risk of fetal loss, providing crucial real-world data to inform life-saving vaccination policies, while acknowledging remaining uncertainties.