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<p>COVID-19 has been a major public health concern for the past five years. While remarkable work has been done to develop therapies, there is still a need for more treatments to fight this disease. Recently, it was suggested that nisin, an FDA-approved antimicrobial compound, may interfere with SARS-CoV-2 entry into host cells. Here, we show that nisin does not inhibit SARS-CoV-2 replication in vitro. Surprisingly, nisin treatment leads to reduced host-cell death during infection in a dose-dependent manner, suggesting that nisin may mitigate SARS-CoV-2-induced pathology.</p>

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The antimicrobial peptide nisin promotes host cell survival during SARS-CoV-2 infection

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月1日

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  • Bevin C. English,
  • Allan Radaic,
  • Ross Barrios-Medina,
  • Kerui Lin,
  • Pachiyappan Kamarajan,
  • Anita Sil,
  • Yvonne L. Kapila

摘要

COVID-19 has been a major public health concern for the past five years. While remarkable work has been done to develop therapies, there is still a need for more treatments to fight this disease. Recently, it was suggested that nisin, an FDA-approved antimicrobial compound, may interfere with SARS-CoV-2 entry into host cells. Here, we show that nisin does not inhibit SARS-CoV-2 replication in vitro. Surprisingly, nisin treatment leads to reduced host-cell death during infection in a dose-dependent manner, suggesting that nisin may mitigate SARS-CoV-2-induced pathology.