Scholarlink

Background <p>We read with great interest Wen et al.‘s article on HPV infection in Huizhou men, commending this pioneering research as the first systematic analysis of HPV epidemiology in the region. The findings, including a 30.53% positivity rate and prevalent genotypes like HPV6, HPV52, HPV11, and HPV16, offer valuable insights for developing effective prevention strategies.</p> Main body <p>We are concerned, however, about the study’s HPV classification methodology. Categorizing infections into “low-risk,” “high-risk,” and “mixed” (which includes any combination of high and low-risk genotypes) might obscure the true incidence of high-risk HPV infections. High-risk HPV types are strongly linked to malignant transformations. Hence, a single high-risk genotype poses a significant health risk, irrespective of low-risk co-infection. Grouping high-risk infections with low-risk types in the “mixed” category could therefore underestimate the proportion of patients with high-risk HPV.</p> Conclusion <p>For future research, we suggest presenting high-risk HPV prevalence by distinguishing between solely low-risk, solely high-risk, and high-risk mixed infections (multiple infections that include at least one high-risk genotype). This offers a more accurate understanding of the burden, aiding public health efforts, screening, and vaccination programs.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Diagnostic criteria for HPV infection classification: a comment on Wen et al.

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月11日

查看全文
  • Elian Analí Camero-Ortiz,
  • Silvia Karen Delgado-García,
  • Guido Bendezu-Quispe,
  • Gustavo A. Grandez-Castillo

摘要

Background

We read with great interest Wen et al.‘s article on HPV infection in Huizhou men, commending this pioneering research as the first systematic analysis of HPV epidemiology in the region. The findings, including a 30.53% positivity rate and prevalent genotypes like HPV6, HPV52, HPV11, and HPV16, offer valuable insights for developing effective prevention strategies.

Main body

We are concerned, however, about the study’s HPV classification methodology. Categorizing infections into “low-risk,” “high-risk,” and “mixed” (which includes any combination of high and low-risk genotypes) might obscure the true incidence of high-risk HPV infections. High-risk HPV types are strongly linked to malignant transformations. Hence, a single high-risk genotype poses a significant health risk, irrespective of low-risk co-infection. Grouping high-risk infections with low-risk types in the “mixed” category could therefore underestimate the proportion of patients with high-risk HPV.

Conclusion

For future research, we suggest presenting high-risk HPV prevalence by distinguishing between solely low-risk, solely high-risk, and high-risk mixed infections (multiple infections that include at least one high-risk genotype). This offers a more accurate understanding of the burden, aiding public health efforts, screening, and vaccination programs.