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<p> <!--Query ID="Q1" Text="We notice that (Graphical abstract) image is corrupted in the package. Could you please check and provide valid image?." Resolved="yes"-->The current worldwide pandemic of monkeypox (MPXV) elicited apprehensions over its possible long-term health ramifications. Recent data indicate a potential association between MPXV infection and the onset of autoimmune disorders, such as type 1 diabetes (T1D). This article analyzes the possible methods for MPXV infection to induce autoimmune responses and damage pancreatic β-cells. We examine from published articles the possible MPXV-induced immune dysregulation and inflammation in the development of T1D. Utilizing insights from other diabetogenic viruses, such as enterovirus and SARS-CoV-2. Currently, the association between MPXV and the development of T1D is scarce. Therefore, additional studies are essential for establishing a conclusive causal link between MPXV and T1D.</p> Graphical abstract <p></p>

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Monkeypox virus and type 1 diabetes: a molecular insight into inflammatory signaling and β-cell autoimmunity

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年6月14日

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  • Yahya A. Almutawif,
  • Haydar M. Al-kuraishy,
  • Ali I. Al-Gareeb,
  • Ali K. Albuhadily,
  • Hamza M. A. Eid,
  • Athanasios Alexiou,
  • Marios Papadakis,
  • Mohammed E. Abo‑El Fetoh,
  • Gaber El-Saber Batiha

摘要

The current worldwide pandemic of monkeypox (MPXV) elicited apprehensions over its possible long-term health ramifications. Recent data indicate a potential association between MPXV infection and the onset of autoimmune disorders, such as type 1 diabetes (T1D). This article analyzes the possible methods for MPXV infection to induce autoimmune responses and damage pancreatic β-cells. We examine from published articles the possible MPXV-induced immune dysregulation and inflammation in the development of T1D. Utilizing insights from other diabetogenic viruses, such as enterovirus and SARS-CoV-2. Currently, the association between MPXV and the development of T1D is scarce. Therefore, additional studies are essential for establishing a conclusive causal link between MPXV and T1D.

Graphical abstract