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<p>This study investigates the early stages of putative sex chromosome evolution in the darkbarbel catfish (<i>Tachysurus vachellii</i>) through whole-genome resequencing of 31 individuals. We identified the sex-determining region (SDR) on chromosome 3 (chr3), with an <i>F</i><sub>ST</sub> value of 0.5, indicating the presence of relatively putative young XY sex chromosomes. Our analyses revealed significant genetic differentiation between male and female groups, suggesting that these young sex chromosomes contribute to observed genetic divergence. Notably, among SDR, pseudoautosomal region (PAR), and autosomes, PAR exhibits the highest synonymous substitutions (<i>d</i><sub>S</sub>) values. And the significantly reduced ratio of nonsynonymous-to-synonymous substitutions (<i>d</i><sub>N</sub>/<i>d</i><sub>S</sub>) in SDR demonstrates intense purifying selection acting on this region, and the progressive <i>d</i><sub>N</sub>/<i>d</i><sub>S</sub> gradient (SDR &lt; PAR &lt; autosomes) reveals an incipient differentiation continuum from PAR to SDR. Our findings provide valuable insights into the dynamics of sex chromosome evolution in fish and underscore the need for further research to explore these mechanisms.</p>

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Whole-genome resequencing reveals chromosomal fusion-driven early stages of XY chromosomes evolution in the darkbarbel catfish (Tachysurus vachellii)

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月18日

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  • Jianjun Liu,
  • Min Tang,
  • Guoqing Duan,
  • Huan Wang,
  • Siqi Liu,
  • Liuwang Nie,
  • Huaxing Zhou

摘要

This study investigates the early stages of putative sex chromosome evolution in the darkbarbel catfish (Tachysurus vachellii) through whole-genome resequencing of 31 individuals. We identified the sex-determining region (SDR) on chromosome 3 (chr3), with an FST value of 0.5, indicating the presence of relatively putative young XY sex chromosomes. Our analyses revealed significant genetic differentiation between male and female groups, suggesting that these young sex chromosomes contribute to observed genetic divergence. Notably, among SDR, pseudoautosomal region (PAR), and autosomes, PAR exhibits the highest synonymous substitutions (dS) values. And the significantly reduced ratio of nonsynonymous-to-synonymous substitutions (dN/dS) in SDR demonstrates intense purifying selection acting on this region, and the progressive dN/dS gradient (SDR < PAR < autosomes) reveals an incipient differentiation continuum from PAR to SDR. Our findings provide valuable insights into the dynamics of sex chromosome evolution in fish and underscore the need for further research to explore these mechanisms.