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Background <p>On May 27, 2025 a measles outbreak was confirmed in Kabulasoke Subcounty, Gomba District, Uganda, following a suspected measles-related death. We investigated the outbreak to determine its magnitude, identify risk factors for transmission, estimate measles-rubella vaccination coverage (VC) and vaccine effectiveness (VE), and inform control measures.</p> Methods <p>We defined a suspected case as onset of fever and maculopapular rash plus ≥ 1 of cough, coryza, or conjunctivitis, in a Kabulasoke Subcounty resident during March–August, 2025; confirmed cases had measles-specific IgM antibodies. We compared exposures of 80 case-patients with 160 age- and sex-matched controls. Vaccination coverage was estimated as the proportion of vaccinated controls; VE was calculated as (1–aOR) *100%, using conditional logistic regression. Sociocultural factors were explored through 15 in-depth and key informant interviews, analysed by inductive thematic analysis.</p> Results <p>We identified 106 cases (5 laboratory-confirmed, 1 death); overall attack rate (AR):2.4/1,000 population. Children aged 9–17 months were most affected (13/1,000), with clustering in infant school X. Response was initiated 33 days after detection. School attendance (aOR = 1.67; 95% CI: 1.05–2.71) and contact with symptomatic peers (aOR = 2.12; 95% CI: 1.21–3.70) were associated with infection, while vaccination was protective (aOR = 0.39; 95% CI: 0.27–0.55). Vaccination coverage was 72%, and VE was 60%. Qualitative findings revealed male-dominated decision-making, vaccine mistrust, and cultural framing of measles as a self-resolving illness as vaccination barriers.</p> Conclusion <p>This outbreak was driven by suboptimal vaccination coverage, school-based transmission, and delayed detection. Strengthening routine immunisation, integrating schools into outbreak prevention, and addressing sociocultural barriers are essential to prevent future outbreaks.</p>

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School-associated measles outbreak driven by vaccination gaps, sociocultural barriers, and delayed detection in Gomba District, Uganda 2025

  • 期刊论文

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  • 发表日期：

    2026年7月10日

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  • Sharon Namasambi,
  • Richard Migisha,
  • Vianney John Kigongo,
  • Maria Nakabuye,
  • Lilian Bulage,
  • Benon Kwesiga,
  • Yasiini Nuwamanya,
  • Fred Nsubuga,
  • Collins Ankunda,
  • James Peter Eliku,
  • Josephine Bwogi,
  • Alex Riolexus Ario

摘要

Background

On May 27, 2025 a measles outbreak was confirmed in Kabulasoke Subcounty, Gomba District, Uganda, following a suspected measles-related death. We investigated the outbreak to determine its magnitude, identify risk factors for transmission, estimate measles-rubella vaccination coverage (VC) and vaccine effectiveness (VE), and inform control measures.

Methods

We defined a suspected case as onset of fever and maculopapular rash plus ≥ 1 of cough, coryza, or conjunctivitis, in a Kabulasoke Subcounty resident during March–August, 2025; confirmed cases had measles-specific IgM antibodies. We compared exposures of 80 case-patients with 160 age- and sex-matched controls. Vaccination coverage was estimated as the proportion of vaccinated controls; VE was calculated as (1–aOR) *100%, using conditional logistic regression. Sociocultural factors were explored through 15 in-depth and key informant interviews, analysed by inductive thematic analysis.

Results

We identified 106 cases (5 laboratory-confirmed, 1 death); overall attack rate (AR):2.4/1,000 population. Children aged 9–17 months were most affected (13/1,000), with clustering in infant school X. Response was initiated 33 days after detection. School attendance (aOR = 1.67; 95% CI: 1.05–2.71) and contact with symptomatic peers (aOR = 2.12; 95% CI: 1.21–3.70) were associated with infection, while vaccination was protective (aOR = 0.39; 95% CI: 0.27–0.55). Vaccination coverage was 72%, and VE was 60%. Qualitative findings revealed male-dominated decision-making, vaccine mistrust, and cultural framing of measles as a self-resolving illness as vaccination barriers.

Conclusion

This outbreak was driven by suboptimal vaccination coverage, school-based transmission, and delayed detection. Strengthening routine immunisation, integrating schools into outbreak prevention, and addressing sociocultural barriers are essential to prevent future outbreaks.