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Background <p><i>Staphylococcus aureus</i> is a major cause of skin, soft tissue, bone, and bloodstream infections. Methicillin-resistant <i>S. aureus</i> presents a significant treatment challenge due to its resistance to multiple drugs. India has some of the highest rates worldwide, but there is limited regional data from Western Maharashtra. This study looked at resistance trends, particularly focusing on vancomycin and inducible clindamycin resistance.</p> Methods <p>Hundred isolates were collected from various clinical samples, including pus, blood, tissue, bronchoalveolar lavage, ear discharge, diabetic ulcers, and osteomyelitis. Identification used standard culture and biochemical tests. Antimicrobial susceptibility followed guidelines through disc diffusion, and vancomycin/teicoplanin MICs and D-tests were also performed.</p> Results and discussion <p>The results showed ciprofloxacin resistance at nearly 80% and erythromycin resistance above 70%. Moderate resistance was found against gentamicin and trimethoprim-sulfamethoxazole. Linezolid and vancomycin had low resistance rates, with less than 5% and 2% respectively, although Minnimum inhibitory concentration creep (0.75–2&#xa0;µg/mL) was noted. Isolates from various intensive care units had higher rates of multidrug resistance, while surgical and obstetric wards had a significant presence of MRSA.</p> Conclusion <p>The present single-centre study identified substantial resistance to fluoroquinolones and macrolides, while vancomycin and linezolid largely retained activity. Routine antimicrobial surveillance, D-test implementation and antimicrobial stewardship programmes may improve the management of <i>Staphylococcus aureus</i> infections in similar tertiary-care settings.</p>

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Antimicrobial resistance patterns and methicillin resistant Staphylococcus aureus among clinical isolates in a tertiary care hospital of Western Maharashtra

  • 期刊论文

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  • 发表日期：

    2026年8月4日

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  • Snehal M. Deshmukhe,
  • Chanda R. Vyawahare,
  • Poonam V. Suryawanshi,
  • Manisha M. Ratnaparkhi

摘要

Background

Staphylococcus aureus is a major cause of skin, soft tissue, bone, and bloodstream infections. Methicillin-resistant S. aureus presents a significant treatment challenge due to its resistance to multiple drugs. India has some of the highest rates worldwide, but there is limited regional data from Western Maharashtra. This study looked at resistance trends, particularly focusing on vancomycin and inducible clindamycin resistance.

Methods

Hundred isolates were collected from various clinical samples, including pus, blood, tissue, bronchoalveolar lavage, ear discharge, diabetic ulcers, and osteomyelitis. Identification used standard culture and biochemical tests. Antimicrobial susceptibility followed guidelines through disc diffusion, and vancomycin/teicoplanin MICs and D-tests were also performed.

Results and discussion

The results showed ciprofloxacin resistance at nearly 80% and erythromycin resistance above 70%. Moderate resistance was found against gentamicin and trimethoprim-sulfamethoxazole. Linezolid and vancomycin had low resistance rates, with less than 5% and 2% respectively, although Minnimum inhibitory concentration creep (0.75–2 µg/mL) was noted. Isolates from various intensive care units had higher rates of multidrug resistance, while surgical and obstetric wards had a significant presence of MRSA.

Conclusion

The present single-centre study identified substantial resistance to fluoroquinolones and macrolides, while vancomycin and linezolid largely retained activity. Routine antimicrobial surveillance, D-test implementation and antimicrobial stewardship programmes may improve the management of Staphylococcus aureus infections in similar tertiary-care settings.