<p>Breast cancer, or neoplasm of the breast, is one of the most common cancers affecting women globally; It can occur in both men and women, but it is more commonly found in women than in men. This research investigated the malignancy solely in women. The study aimed to explore the impact of lifestyle, family history, and environmental factors on the development of breast cancer among 80 women in hospitals in the Calabar metropolis. A purposive sampling technique (census approach) was employed, wherein all historical records within the Calabar cancer registry matching the inclusion parameters between 2014 and 2024 were extracted. Regression analysis was used to assess the relationship between these factors and the development of breast cancer. The coefficient of determination (R²) values of 0.11, 0.16, and 0.60 for lifestyle, environmental, and family history factors, respectively, suggested that these factors have 11%, 16%, and 60% influence on the development of breast cancer among the studied population. However, the results of the study also indicated that lifestyle, environmental, and familial history factors did not have a significant impact on the development of breast cancer among the participants, as the associated probability values were greater than the level of significance (P &lt; 0.05) for all the three factors.</p>