Background <p>Telemedicine became an essential mode of healthcare delivery during the COVID-19 pandemic, particularly for patients managing chronic diseases. While telemedicine adoption increased in the United Arab Emirates (UAE), there is limited qualitative evidence regarding patient experiences in management of chronic conditions.</p> Objective <p>This study explored patient perspectives on use of telemedicine for chronic disease management in Abu Dhabi during the COVID-19 pandemic.</p> Methods <p>A qualitative design using semi-structured interviews was conducted with 17 adults residing in the UAE and diagnosed with diabetes, hypertension, or cardiovascular disease who accessed telemedicine services between 2020 and 2021. Interviews were thematically analyzed, guided by the Diffusion of Innovations (DOI) framework.</p> Results <p>Analysis resulted in five themes based on DOI framework: relative advantage, compatibility, complexity, trialability, and observability, along with one emergent theme reflecting service gaps. Participants valued telemedicine for convenience, time savings, and reduced exposure risk, particularly for routine follow-ups. However, challenges included limited emotional engagement, technological difficulties, digital literacy barriers, and diagnostic constraints related to the absence of physical examination. Acceptance varied by age, technological confidence, and clinical complexity, with many participants expressing preference for hybrid care models combining virtual and in-person services.</p> Conclusion <p>Telemedicine supported continuity of care during COVID-19 yet was not universally suitable for chronic disease management. Sustainable implementation requires patient-centered hybrid models that integrate digital convenience with clinical depth, emotional reassurance, and accessible support systems.</p>