Background <p>Hepatitis B and hepatitis C viruses remain a major public health problem in Yemen, although their Seroprevalence among different population groups remains limited. However, information on these infections among secondary school students in Yemen is still scarce.</p> Objectives <p>This study aimed to estimate the seroprevalence of hepatitis B surface antigen (HBsAg) and anti-HCV and their associated risk factors among secondary school students in Jiblah Town, Yemen.</p> Methods and materials <p>A cross-sectional study was conducted on 100 secondary school students in Jiblah town, Yemen. Serum samples were tested for hepatitis B surface antigen and hepatitis C antibodies using a rapid assay. Positive results were confirmed using enzyme-linked immunosorbent assay. A structured interviewing questionnaire was used to collect sociodemographic data from the target sample. Chi-square tests were used to analyze the results.</p> Results <p>The overall seroprevalence of HBV was 1(1%), while the seroprevalence of HCV was4 (4%). Statistically significant association was found between HCV infection and the gender of the participants.</p> Conclusions <p>This study highlighted the need to expand hepatitis B immunization coverage in the study area. It also revealed a moderate risk of hepatitis C infection. Therefore, educational campaigns should be implemented to raise students’ awareness of the seroprevalence of viral hepatitis and its risk determinants.</p>