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<p>Globally, tuberculosis (TB) remains the foremost infectious cause of death. Additionally, poor quality of life (QOL) is commonplace in affected individuals and constitutes a significant factor contributing to treatment failure and poor prognosis. This study aims to evaluate health-related QOL among Afghan TB patients. This cross-sectional study used data from five healthcare facilities in Southern Afghanistan. Data were collected between July and September 2025. Health-related QOL was assessed using the WHO-QOL-BREF (Pashtu version). The binary outcome health-related QOL (poor vs. good) was used in a multivariable logistic regression model. Sociodemographic and clinical variables were included in the logistic regression model. Overall, 70.8% of TB patients had poor health-related QOL. The highest (52.58 ± 20.18) and the lowest (32.52 ± 14.53) scores were observed in the social and psychological domains, respectively. In adjusted models, odds of poor health-related QOL were higher among rural residents (AOR 1.96; 95% CI 1.18–3.26), the uneducated (AOR 1.83; 95% CI 1.04–3.21), patients with severe disease (AOR 3.50; 95% CI 2.12–5.76), current smokers (AOR 3.56; 95% CI 1.17–10.79), those with no counselling during treatment (AOR 3.21; 95% CI 1.21–8.50), and those with medical comorbidity (AOR 2.08; 95% CI 1.26–3.44). TB patients in Southern Afghanistan have a poor health-related QOL. The study underscores the urgent need for interventions to better protect and improve the health-related QOL in this population.&#xa0;</p>

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Health-related quality of life among patients with tuberculosis in Afghanistan

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月10日

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  • Muhammad Haroon Stanikzai,
  • Bashir Ahmad Mahboobi,
  • Ghulam Mohayuddin Mudaser,
  • Hazratullah Bariz,
  • Zabihullah Anwary,
  • Ahmad Haroon Baray

摘要

Globally, tuberculosis (TB) remains the foremost infectious cause of death. Additionally, poor quality of life (QOL) is commonplace in affected individuals and constitutes a significant factor contributing to treatment failure and poor prognosis. This study aims to evaluate health-related QOL among Afghan TB patients. This cross-sectional study used data from five healthcare facilities in Southern Afghanistan. Data were collected between July and September 2025. Health-related QOL was assessed using the WHO-QOL-BREF (Pashtu version). The binary outcome health-related QOL (poor vs. good) was used in a multivariable logistic regression model. Sociodemographic and clinical variables were included in the logistic regression model. Overall, 70.8% of TB patients had poor health-related QOL. The highest (52.58 ± 20.18) and the lowest (32.52 ± 14.53) scores were observed in the social and psychological domains, respectively. In adjusted models, odds of poor health-related QOL were higher among rural residents (AOR 1.96; 95% CI 1.18–3.26), the uneducated (AOR 1.83; 95% CI 1.04–3.21), patients with severe disease (AOR 3.50; 95% CI 2.12–5.76), current smokers (AOR 3.56; 95% CI 1.17–10.79), those with no counselling during treatment (AOR 3.21; 95% CI 1.21–8.50), and those with medical comorbidity (AOR 2.08; 95% CI 1.26–3.44). TB patients in Southern Afghanistan have a poor health-related QOL. The study underscores the urgent need for interventions to better protect and improve the health-related QOL in this population.