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Background <p>Alcohol dependence is often associated with various medical and psychiatric conditions, that influence overall treatment outcomes. Available evidence largely comes from single-centre epidemiological studies with no comprehensive data on comorbidity patterns among treatment-seeking populations.</p> Aims <p>To examine proportion and patterns of medical and psychiatric comorbidities among treatment-seeking patients with alcohol dependence across multiple centres in India, and to evaluate variations across centres.</p> Methods <p>This multicentric, cross-sectional observational study was conducted across 16 institutes in India from December 2023 to December 2024. Adults aged 18 years and above, diagnosed with alcohol dependence according to ICD-11 were included using purposive sampling. Structured checklist and Charlson Comorbidity Index were used to document medical comorbidities. Psychiatric comorbidities were documented based on routine clinical diagnostic interviews based on ICD-11.</p> Results <p>A total of 1850 patients were enrolled in the study with mean age of 39.6 years and male predominance (98.5%). At least one medical comorbidity was present in 48.1% of patients, most common being acid peptic disease (26%), followed by hypertension (12.1%). At least one psychiatric diagnosis apart from substance dependence was present in 23.0% of the participants. The common psychiatric comorbidities included single-episode major depressive disorder (4.1%), personality disorder (3.3%), and generalized anxiety disorder (2.9%). Notable regional variations in comorbidity patterns were observed.</p> Conclusions <p>This large-scale multi-centre study reveals a considerable proportion of patients having medical and psychiatric comorbidity. Also, variations in comorbidities exist across the treatment settings, which may be attributable to population, provider, or treatment setting characteristics.</p>

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A multicentric Indian cross-sectional study on medical and psychiatric comorbidities among patients with alcohol dependence

  • 期刊论文

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  • 发表日期：

    2026年5月8日

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  • Balaji Bharadwaj,
  • Ragul Ganesh,
  • Bandita Abhijita,
  • Subashree Kathatharan,
  • Amit Singh,
  • Mohita Joshi,
  • Sujita Kumar Kar,
  • Diptadhi Mukherjee,
  • Phurailatpam Shivraj Sharma,
  • Bipul Sharma,
  • Tathagata Mahintamani,
  • Abhishek Ghosh,
  • Vidur Makkar,
  • Mondeep Dhankar,
  • B. N. Subodh,
  • Sambhu Prasad,
  • Pankaj Kumar,
  • Richa Tripathi,
  • Mohd. Rashid Alam,
  • Shubhankar Tiwary,
  • Manoj Prithviraj,
  • Ganesh Kumar Mallaram,
  • Durganjali Boggula,
  • Raghav Kannappan,
  • Dulla S. N. Nireesha,
  • Nandhini Bojappen,
  • Aishwariya Jha,
  • Lekhansh Shukla,
  • Jayant Mahadevan,
  • Arpit Parmar,
  • Debadatta Mohapatra,
  • Dibyendu Mohanty,
  • Gayatri Bhatia,
  • Mohit Suva,
  • Siddharth Sarkar,
  • Yatan Pal Singh Balhara,
  • Vipindeep Kaur Sandhu,
  • Vishal Dhiman,
  • Tanve Garg,
  • Jawahar Singh,
  • Bharat Udey,
  • Mahak Aggarwal,
  • Aniruddha Basu,
  • Kamini Verma,
  • Trisha Chakraborty,
  • Tamonud Modak,
  • Sourav Khanra,
  • Aniruddha Mukherjee,
  • Sanjay Kumar Munda

摘要

Background

Alcohol dependence is often associated with various medical and psychiatric conditions, that influence overall treatment outcomes. Available evidence largely comes from single-centre epidemiological studies with no comprehensive data on comorbidity patterns among treatment-seeking populations.

Aims

To examine proportion and patterns of medical and psychiatric comorbidities among treatment-seeking patients with alcohol dependence across multiple centres in India, and to evaluate variations across centres.

Methods

This multicentric, cross-sectional observational study was conducted across 16 institutes in India from December 2023 to December 2024. Adults aged 18 years and above, diagnosed with alcohol dependence according to ICD-11 were included using purposive sampling. Structured checklist and Charlson Comorbidity Index were used to document medical comorbidities. Psychiatric comorbidities were documented based on routine clinical diagnostic interviews based on ICD-11.

Results

A total of 1850 patients were enrolled in the study with mean age of 39.6 years and male predominance (98.5%). At least one medical comorbidity was present in 48.1% of patients, most common being acid peptic disease (26%), followed by hypertension (12.1%). At least one psychiatric diagnosis apart from substance dependence was present in 23.0% of the participants. The common psychiatric comorbidities included single-episode major depressive disorder (4.1%), personality disorder (3.3%), and generalized anxiety disorder (2.9%). Notable regional variations in comorbidity patterns were observed.

Conclusions

This large-scale multi-centre study reveals a considerable proportion of patients having medical and psychiatric comorbidity. Also, variations in comorbidities exist across the treatment settings, which may be attributable to population, provider, or treatment setting characteristics.