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<p>This review examines antimicrobial resistance (AMR) in Sub-Saharan Africa (SSA) through an integrated One Health lens, synthesizing evidence across human, animal, and environmental domains. As one of the twenty-first century’s biggest public health threats, AMR represents a particularly significant challenge in the resource-constrained settings of SSA, where surveillance systems remain fragmented and implementation of national action plans is often limited. Drawing on recent surveillance data, genomic studies, and policy analyses, this review provides a comprehensive assessment of AMR epidemiology across all three One Health sectors. It critically evaluates existing cross-sectoral surveillance frameworks, identifies key drivers of resistance transmission between compartments, and examines successful implementation of antimicrobial stewardship programs across the region. The review highlights significant knowledge gaps, particularly regarding environmental reservoirs and animal–human transmission pathways, while proposing context-appropriate interventions aligned with the 2024 WHO AMR Action Plan.</p>

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A one health perspective on antimicrobial resistance in Sub-Saharan Africa: synthesizing human, animal, and environmental evidence for integrated action

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月18日

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  • Yakub Burhan Abdullahi,
  • Naima Ibrahim Ahmed,
  • Yusuf Hared Abdi,
  • Sharmake Gaiye Bashir,
  • Mohamed Sharif Abdi,
  • Saadaq Adan Hussein,
  • Marian Muse Osman,
  • Mohamed Mohamoud Hassan,
  • Abdirahman Aden Hussein,
  • Fadumo Abdisamed Mohamed,
  • Abdinur Hussein Mohamed,
  • Rage Adem,
  • Abdirahman Moallim Ibrahim,
  • Abdihakim Ibrahim Ahmed,
  • Ayan Nur Ali,
  • Abdinur Adan Hussein

摘要

This review examines antimicrobial resistance (AMR) in Sub-Saharan Africa (SSA) through an integrated One Health lens, synthesizing evidence across human, animal, and environmental domains. As one of the twenty-first century’s biggest public health threats, AMR represents a particularly significant challenge in the resource-constrained settings of SSA, where surveillance systems remain fragmented and implementation of national action plans is often limited. Drawing on recent surveillance data, genomic studies, and policy analyses, this review provides a comprehensive assessment of AMR epidemiology across all three One Health sectors. It critically evaluates existing cross-sectoral surveillance frameworks, identifies key drivers of resistance transmission between compartments, and examines successful implementation of antimicrobial stewardship programs across the region. The review highlights significant knowledge gaps, particularly regarding environmental reservoirs and animal–human transmission pathways, while proposing context-appropriate interventions aligned with the 2024 WHO AMR Action Plan.