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Background <p>Providing mental health services for transgender individuals within primary care is imperative due to the unique challenges they face. Transgender people experience elevated discrimination, stigma, and social exclusion, increasing mental health risks especially in low- and middle-income countries such as Pakistan. Primary care offers accessible, inclusive platforms to address these needs, enabling supportive environments for timely interventions. Early identification can mitigate psychological distress, depression, and anxiety. Integrating services within primary care promotes holistic care and fosters safe spaces where transgender individuals feel understood, validated, and empowered. This study aims to estimate levels of depression, anxiety, and suicidal ideation among transgender individuals, and to pilot a mental health gap action program (mhGAP)-based intervention for common mental disorders in primary healthcare settings in Peshawar, Pakistan.</p> Methods <p>We will conduct an 18-month mixed-methods pilot feasibility study employing a single-arm pre–post design in primary care, including general practitioner (GP) clinics in Peshawar, Khyber Pakhtunkhwa. A sample of 144 transgender participants scoring ≥ 3 on both PHQ-2 and GAD-2 at screening will be enrolled. Participants will be referred to GPs trained in mhGAP to diagnose depression, anxiety, and suicidal ideation, and to deliver focused cognitive behavioral therapy sessions. Outcomes will be assessed at baseline, 2nd months, and 4th month. Fidelity to mhGAP protocols will be monitored through supervision, checklists, and refresher training for GPs. Pre and post-intervention anxiety and depression scores will be compared using SPSS version 29.0.</p> Discussion <p>Findings will offer an evidence-based pathway for integrating mental health care for transgender individuals in primary care, improving detection and management of common mental disorders, and informing scale-up in similar low-resource contexts. We anticipate improved symptoms, reduced suicidal ideation, and enhanced engagement with inclusive, supportive services.</p> Trial registration <p>This pilot feasibility trial is registered with the ISRCTN registry (ISRCTN12146586).</p>

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A mixed-methods study protocol for integrating mental health services into primary care for transgender communities through the mhGAP intervention (MenTra) in Pakistan

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月15日

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  • Saima Aleem,
  • Mariyam Rahim,
  • Zeeshan Kibria,
  • Fayaz Ahmad,
  • Mirrat Gul,
  • Sania Abdul Jalil,
  • Faryal Fazal,
  • Saara Khan,
  • Ishfaq Tariq,
  • Syed Muhammad Uzair Shah,
  • Taha Ayub,
  • Zohaib Khan,
  • Abdul Jalil Khan

摘要

Background

Providing mental health services for transgender individuals within primary care is imperative due to the unique challenges they face. Transgender people experience elevated discrimination, stigma, and social exclusion, increasing mental health risks especially in low- and middle-income countries such as Pakistan. Primary care offers accessible, inclusive platforms to address these needs, enabling supportive environments for timely interventions. Early identification can mitigate psychological distress, depression, and anxiety. Integrating services within primary care promotes holistic care and fosters safe spaces where transgender individuals feel understood, validated, and empowered. This study aims to estimate levels of depression, anxiety, and suicidal ideation among transgender individuals, and to pilot a mental health gap action program (mhGAP)-based intervention for common mental disorders in primary healthcare settings in Peshawar, Pakistan.

Methods

We will conduct an 18-month mixed-methods pilot feasibility study employing a single-arm pre–post design in primary care, including general practitioner (GP) clinics in Peshawar, Khyber Pakhtunkhwa. A sample of 144 transgender participants scoring ≥ 3 on both PHQ-2 and GAD-2 at screening will be enrolled. Participants will be referred to GPs trained in mhGAP to diagnose depression, anxiety, and suicidal ideation, and to deliver focused cognitive behavioral therapy sessions. Outcomes will be assessed at baseline, 2nd months, and 4th month. Fidelity to mhGAP protocols will be monitored through supervision, checklists, and refresher training for GPs. Pre and post-intervention anxiety and depression scores will be compared using SPSS version 29.0.

Discussion

Findings will offer an evidence-based pathway for integrating mental health care for transgender individuals in primary care, improving detection and management of common mental disorders, and informing scale-up in similar low-resource contexts. We anticipate improved symptoms, reduced suicidal ideation, and enhanced engagement with inclusive, supportive services.

Trial registration

This pilot feasibility trial is registered with the ISRCTN registry (ISRCTN12146586).