Scholarlink

Background <p>Preventive health practices are considered important in the management of sickle cell disease (SCD), yet their impact on clinical outcomes remains uncertain in low-resource settings. This study aimed to assess the relationship between preventive health behaviours and clinical outcomes among individuals with SCD in Nigeria.</p> Methods <p>An analytical cross-sectional study was conducted among participants at the 2022 World Sickle Cell Day celebration. Preventive health practices and clinical complications frequency of vaso-occlusive crises, and annual blood transfusion frequency were recorded. Analyses were performed in SPSS version 25 using descriptive statistics, independent-samples t-tests, chi-square tests, binary logistic regression for predictors of complications, and multinomial logistic regression for transfusion frequency. Significance was set at <i>p</i> &lt; 0.05.</p> Results <p>Seventy-six individuals with SCD were included, and 50 (65.8%) reported complications. Reported preventive practices included hydration (73.7%), mosquito net use (53.9%), clinic attendance (47.4%), stress avoidance (60.5%), and routine medication use (98.7%). Mosquito net use was significantly associated with lower frequency of blood transfusions (AOR = 0.089, 95% CI: 0.012–0.640, <i>p</i> = 0.016). No other preventive behaviours showed significant associations with complications or transfusion frequency.</p> Conclusion <p>Among this SCD cohort, most preventive health practices were not significantly associated with complications, whereas older age was the strongest predictor and mosquito net use reduced the likelihood of transfusion. These findings emphasize the greater impact of biological progression and malaria prevention compared to general self-care, highlighting the need for multicentre studies to validate and guide comprehensive interventions in sub-Saharan Africa.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Preventive health practices and clinical outcomes in sickle cell disease: insights from the 2022 world sickle cell day celebration

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年1月25日

查看全文
  • Chilota Chibuife Efobi,
  • Chijioke G. Egbunike,
  • Bruno Basil,
  • Nwanneka Ugwu,
  • Somtoo Ngonadi,
  • Chisom Nri-Ezedi

摘要

Background

Preventive health practices are considered important in the management of sickle cell disease (SCD), yet their impact on clinical outcomes remains uncertain in low-resource settings. This study aimed to assess the relationship between preventive health behaviours and clinical outcomes among individuals with SCD in Nigeria.

Methods

An analytical cross-sectional study was conducted among participants at the 2022 World Sickle Cell Day celebration. Preventive health practices and clinical complications frequency of vaso-occlusive crises, and annual blood transfusion frequency were recorded. Analyses were performed in SPSS version 25 using descriptive statistics, independent-samples t-tests, chi-square tests, binary logistic regression for predictors of complications, and multinomial logistic regression for transfusion frequency. Significance was set at p < 0.05.

Results

Seventy-six individuals with SCD were included, and 50 (65.8%) reported complications. Reported preventive practices included hydration (73.7%), mosquito net use (53.9%), clinic attendance (47.4%), stress avoidance (60.5%), and routine medication use (98.7%). Mosquito net use was significantly associated with lower frequency of blood transfusions (AOR = 0.089, 95% CI: 0.012–0.640, p = 0.016). No other preventive behaviours showed significant associations with complications or transfusion frequency.

Conclusion

Among this SCD cohort, most preventive health practices were not significantly associated with complications, whereas older age was the strongest predictor and mosquito net use reduced the likelihood of transfusion. These findings emphasize the greater impact of biological progression and malaria prevention compared to general self-care, highlighting the need for multicentre studies to validate and guide comprehensive interventions in sub-Saharan Africa.