Objective <p>This article explores the health information-seeking behaviour and search channels of undergraduate students in Tanzania.</p> Methods <p>The study employs a mixed-methods approach, collecting data through questionnaires and semi-structured interviews. A total of 402 questionnaires and 20 interviews were used to collect primary data. Data were analysed using descriptive statistics and thematic analysis.</p> Results <p>The study revealed that the desire to prevent illness and stay healthy, experiencing health symptoms or illness, the desire to make informed decisions about health, advice from family and peers, and curiosity about health-related issues were the motives behind seeking health information among the respondents. Sexual and reproductive health, preventive healthcare, and mental health information were the primary types of health information sought by undergraduate students. While healthcare providers remain an essential source of health information, the study revealed an increase in reliance on the internet and social media, along with a declining trend in reliance on print media as sources of health information. Different barriers preventing respondents from accessing health information were also identified, primarily limited internet access and language barriers.</p> Conclusion <p>The study concludes that health information is one of the most important issues that should be given priority in higher education institutions, given its significant role in enhancing public health. The study highlights the need for universities to invest more in digital technological resources to ensure that undergraduate students have access to appropriate and timely health information.</p>