<p>The primary purpose of this study is to systematically review the effect of different hazardous work environment among workers in the informal sector across of India, with a particular emphasis on respiratory health risks. The research question focuses on identifying the types of occupational exposures that threaten respiratory health and assessing the efficacy of current health policies and interventions for these workers. This systematic review critically analyzes literature from 2013 to 2023, focusing on studies that investigate occupational exposures on respiratory health among informal sector workers in India and different intervention strategies to control the problems. Of these, 17 studies focused on respiratory health impacts, while 11 examined intervention strategies. Databases such as PubMed, Scopus, and Google Scholar etc. were searched using a structured strategy, adhering to PRISMA guidelines. Only peer-reviewed English-language studies were included, which may introduce language bias and limit the generalizability of findings. Common occupational exposures identified include dust and chemical vapours, which were significantly associated with conditions such as asthma and chronic respiratory diseases. Quantitative insights revealed that workers exposed to high dust levels had a threefold increased risk of chronic bronchitis, while intervention studies highlighted improvements in respiratory health through measures like enhanced ventilation systems and use of personal protective equipment. The study highlights gaps in implementing effective health policies, emphasizing the severe respiratory risks faced by informal sector workers in India and the urgent need for comprehensive occupational health measures. The conclusions emphasize the need for targeted interventions, including stronger policies, better workplace practices, and enhanced worker education, to reduce occupational hazards and improve health outcomes.</p>