Introduction <p>In some countries in sub-Saharan Africa, there is a lack of awareness of risk factors and preventive strategies for cervical cancer. Therefore, there is a need to assess the knowledge and preventive practices against cervical cancer.</p> Objective <p>To assess the knowledge, attitude, and preventive practices for cervical cancer risk factors among female secondary school students of Enugu North Senatorial District, Enugu state.</p> Method <p>A descriptive cross-sectional questionnaire-based survey was conducted in five local government areas of Enugu-North senatorial district, Enugu State, from February 2022–September 2022. The study was conducted among female senior secondary school students. Descriptive (frequency and percentages) and inferential statistics (Chi-square to test for association) were conducted, and Statistical significance was set at p &lt; 0.05.</p> Results <p>Out of the total respondents (n = 588), the majority, 577(98.1%) had poor knowledge of cervical cancer, and 555(94.4%) had poor attitude toward the cancer risk factors. The majority, 585(99.5%), had poor attitude towards preventive practices on cervical cancer. Willingness to take the Human Papillomavirus (HPV) vaccine was significantly associated with knowledge (p = 0.021) and preventive practices (p = 0.023). Attitude of the participants was significantly associated with willingness to take the HPV vaccine (p = 0.000<b>)</b> and to undergo cervical screening (p = 0.043). A high percentage of the students had poor knowledge of cervical cancer (98.1%).</p> Conclusion <p>Majority of the students had poor knowledge, poor attitudes and poor preventive practice towards cervical cancer risk factors.</p>