Influence of socio-environmental factors on stress and chronic disease in an urban population

The primary purpose of this project is to identify the modifiable individual, social and environmental factors associated with stress and to investigate and quantify the effect of persistent stress on chronic disease in a marginalized, primarily minority, urban community.

This study leveraged data collected as part of Temple Health: Block-By-Block, a longitudinal cohort study conducted over five years in an underserved community. Through in-home visits, 385 subjects completed a Visit 5 Social & Environmental Assessment which measured individual, social, neighborhood, and environmental factors as reported through each participant’s perspectives. A Perceived Stress Scale and a Cumulative Chronic Disease Index was also completed during this visit.

Five of sixteen modifiable risk factors were identified as significant, independent predictors of stress, including general health, employment status, difficulties in paying for basics, home ownership and overall neighborhood quality. These health determinants combined with stress scores significantly predicted chronic disease burden.

This study provides unique, individualized evidence regarding the impact of social determinants of health on levels of stress among community residents, and suggests that stress is an intervening factor in the path to chronic disease. While addressing social determinants of health must be a priority, this study indicates that actionable behavioral and pharmacologic interventions to reduce stress may provide more immediate improvements in prevention and reduction of chronic disease in diverse urban communities.