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Background <p>We assessed whether participants in the EZI-PrEP study, a non-inferiority trial evaluating online and six-monthly monitoring of oral HIV pre-exposure prophylaxis (PrEP), represent the broader population of PrEP users in the Netherlands.</p> Methods <p>We conducted a cross-sectional study using routinely collected data from September 2021 to August 2022 at four centres for sexual health (CSHs) in the Netherlands. Socio-demographic characteristics, sexual behaviour, and prevalence of bacterial STIs were compared between EZI-PrEP participants at baseline and other PrEP users during their first PrEP monitoring visit during the same period.</p> Results <p>The analysis included 469 EZI-PrEP participants and 5161 other PrEP users, of whom 99% and 96% were men who have sex with men (MSM), respectively. EZI-PrEP participants were less often transgender or gender-divers persons (TGDP) (1% vs. 4%, <i>p</i> &lt; 0.001), older (median age = 36 vs. 34 years, <i>p</i> = 0.004), more often born in the Netherlands (68% vs. 58%, <i>p</i> &lt; 0.001), and more often completed a university/college degree (81% vs. 76%, <i>p</i> = 0.01). They also reported more group sex (38% vs. 33%, <i>p</i> = 0.023) and condomless anal sex (95% vs. 92%, <i>p</i> = 0.004), but less often sex work (1% vs. 6%, <i>p</i> &lt; 0.001). Prevalence of bacterial STIs were no different between groups (19% vs. 18%, <i>p</i> = 0.77).</p> Conclusions <p>The comparable STI prevalence suggests no difference in risk for HIV acquisition among EZI-PrEP participants and other PrEP users, making study outcomes applicable to a broader population of PrEP users. However, under-representation of TGDPs, sex workers, individuals not born in the Netherlands, and individuals without university or college degree may limit generalizability.</p>

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Representativeness of participants in a randomized controlled trial on modalities of monitoring oral HIV pre-exposure prophylaxis use

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月13日

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  • Marije L. Groot Bruinderink,
  • Maarten F. Schim Van Der Loeff,
  • Florien Dusseldorp,
  • Katja Van Der Velde,
  • Laura Blitz,
  • Jean-Marie Brand,
  • Colette Van Bokhoven,
  • Joey Woudstra,
  • Koenraad Vermey,
  • Sophie Boers,
  • Maudy Sluimer,
  • Hannelore M. Götz,
  • Anders Boyd,
  • Lotte Werner,
  • Maaike L. Soors d’Ancona,
  • Frenk Van Harreveld,
  • Maria Prins,
  • Elske Hoornenborg,
  • Udi Davidovich,
  • Vita W. Jongen

摘要

Background

We assessed whether participants in the EZI-PrEP study, a non-inferiority trial evaluating online and six-monthly monitoring of oral HIV pre-exposure prophylaxis (PrEP), represent the broader population of PrEP users in the Netherlands.

Methods

We conducted a cross-sectional study using routinely collected data from September 2021 to August 2022 at four centres for sexual health (CSHs) in the Netherlands. Socio-demographic characteristics, sexual behaviour, and prevalence of bacterial STIs were compared between EZI-PrEP participants at baseline and other PrEP users during their first PrEP monitoring visit during the same period.

Results

The analysis included 469 EZI-PrEP participants and 5161 other PrEP users, of whom 99% and 96% were men who have sex with men (MSM), respectively. EZI-PrEP participants were less often transgender or gender-divers persons (TGDP) (1% vs. 4%, p < 0.001), older (median age = 36 vs. 34 years, p = 0.004), more often born in the Netherlands (68% vs. 58%, p < 0.001), and more often completed a university/college degree (81% vs. 76%, p = 0.01). They also reported more group sex (38% vs. 33%, p = 0.023) and condomless anal sex (95% vs. 92%, p = 0.004), but less often sex work (1% vs. 6%, p < 0.001). Prevalence of bacterial STIs were no different between groups (19% vs. 18%, p = 0.77).

Conclusions

The comparable STI prevalence suggests no difference in risk for HIV acquisition among EZI-PrEP participants and other PrEP users, making study outcomes applicable to a broader population of PrEP users. However, under-representation of TGDPs, sex workers, individuals not born in the Netherlands, and individuals without university or college degree may limit generalizability.