Scholarlink

Introduction <p>HIV stigma negatively impacts multiple outcomes for persons living with HIV (PLHIV). Among older PLHIV, stigma may influence mental health and aging expectation. We aimed to evaluate factors related to HIV stigma and whether depression mediates its association with expectations regarding aging (ERA-12).</p> Design <p>Cross-sectional study of PLHIV ≥ 50&#xa0;years, on antiretroviral therapy with suppressed viral load, enrolled in the Longitudinal Study of HIV &amp; Aging in Brazil (ELEA-Brasil).</p> Methods <p>We assessed factors related to HIV stigma (12-item Berger, range:12–48, higher = higher stigma) and associated with ERA-12 (range: 0–100, lower = more negative aging expectation). Mediation analysis was performed to evaluate depression (Patient Health Questionnaire-9 [PHQ-9]; range:0–27, higher = higher symptoms) as a mediator of the association between stigma and ERA-12. Univariable and multivariable Poisson and linear regression models were applied, adjusted for demographics, time since HIV diagnosis, and substance use.</p> Results <p>We enrolled 702 PLHIV (median age 62&#xa0;years; 64.9% men). Median and interquartile range (IQR) of HIV stigma, ERA-12 and PHQ-9 were 30 (25–35); 36 (22–47) and 3 (1–7) respectively. In adjusted analyses, older age (≥ 70 vs. 50–55&#xa0;years) and shorter time since HIV diagnosis (10–19&#xa0;years vs. ≥ 20&#xa0;years) were significantly associated with lower HIV stigma. In adjusted models, higher HIV stigma (Coefficient = − 12.05 [95%CI − 17.84, − 6.26]) and lower education (Coefficient = − 7.60 [95%CI: − 13.40, − 1.81]) were associated with worse ERA-12. Depressive symptoms may reflect 25% of the overall effect of stigma on ERA-12.</p> Conclusion <p>We observed a high prevalence of HIV stigma, with depressive symptoms consistent with a potential mediating role in aging expectations.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Stigma, depression, and poor expectations regarding aging among older adults with HIV in Brazil

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月4日

查看全文
  • Marília Bordignon Antonio,
  • Thiago S. Torres,
  • Paula M. Luz,
  • Beatriz Grinsztejn,
  • Sandra W. Cardoso,
  • Roberta S. Nogueira,
  • Lucas R. Ramos,
  • José Valdez R. Madruga,
  • Carlos Brites,
  • Estela Luz,
  • Tamara Cordeiro,
  • Márlon J. R. Aliberti,
  • Esper G. Kallás,
  • Jessica L. Castilho

摘要

Introduction

HIV stigma negatively impacts multiple outcomes for persons living with HIV (PLHIV). Among older PLHIV, stigma may influence mental health and aging expectation. We aimed to evaluate factors related to HIV stigma and whether depression mediates its association with expectations regarding aging (ERA-12).

Design

Cross-sectional study of PLHIV ≥ 50 years, on antiretroviral therapy with suppressed viral load, enrolled in the Longitudinal Study of HIV & Aging in Brazil (ELEA-Brasil).

Methods

We assessed factors related to HIV stigma (12-item Berger, range:12–48, higher = higher stigma) and associated with ERA-12 (range: 0–100, lower = more negative aging expectation). Mediation analysis was performed to evaluate depression (Patient Health Questionnaire-9 [PHQ-9]; range:0–27, higher = higher symptoms) as a mediator of the association between stigma and ERA-12. Univariable and multivariable Poisson and linear regression models were applied, adjusted for demographics, time since HIV diagnosis, and substance use.

Results

We enrolled 702 PLHIV (median age 62 years; 64.9% men). Median and interquartile range (IQR) of HIV stigma, ERA-12 and PHQ-9 were 30 (25–35); 36 (22–47) and 3 (1–7) respectively. In adjusted analyses, older age (≥ 70 vs. 50–55 years) and shorter time since HIV diagnosis (10–19 years vs. ≥ 20 years) were significantly associated with lower HIV stigma. In adjusted models, higher HIV stigma (Coefficient = − 12.05 [95%CI − 17.84, − 6.26]) and lower education (Coefficient = − 7.60 [95%CI: − 13.40, − 1.81]) were associated with worse ERA-12. Depressive symptoms may reflect 25% of the overall effect of stigma on ERA-12.

Conclusion

We observed a high prevalence of HIV stigma, with depressive symptoms consistent with a potential mediating role in aging expectations.