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<p>HIV infection profoundly impacts both the immune and hematologic systems. This retrospective study aimed to assess the effect of CD4<sup>+</sup> T-cell depletion on peripheral immune and hematologic cell populations in 1293 people living with HIV (PLWH). Patients with CD4<sup>+</sup> counts &lt; 200 cells/µL exhibited significant reductions in neutrophils (4000 ± 1200 cells/µL), eosinophils (150 ± 50 cells/µL), basophils (30 ± 10 cells/µL), monocytes (300 ± 100 cells/µL), erythrocytes (4.3 ± 0.6 × 10<sup>6</sup>/µL), and platelets (268 ± 78 × 10<sup>3</sup>/µL). As evaluated in 93 PLWH cases, B cells showed a similar trend (150 ± 50 cells/µL), while the decrease of NK cells was not significant (200 ± 70 cells/µL),. In parallel, we observed a compensatory increase in CD8<sup>+</sup> T lymphocytes (850 ± 300 cells/µL). These findings highlight the complex interplay between CD4<sup>+</sup> T-cell depletion and both immune and hematologic cells in the context of HIV infection, which emphasizes the need for integrated monitoring to inform targeted interventions and optimize clinical outcomes.</p>

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Immune and hematologic alterations associated with CD4+ T-cell depletion in people living with HIV in Morocco

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月26日

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  • Zakaria Elkodmiri,
  • Abdelmouine Salami,
  • Moulay Yassine Belghali,
  • Rajaa Hazime,
  • Fatima-Ezzohra Eddehbi,
  • Saad Lamjadli,
  • Salma Rouhi,
  • Wafaa Qiddi,
  • Sanaa Sayagh,
  • Malika Idalene,
  • Maryame Ahnach,
  • Noura Tassi,
  • Bouchra Ghazi,
  • Brahim Admou

摘要

HIV infection profoundly impacts both the immune and hematologic systems. This retrospective study aimed to assess the effect of CD4+ T-cell depletion on peripheral immune and hematologic cell populations in 1293 people living with HIV (PLWH). Patients with CD4+ counts < 200 cells/µL exhibited significant reductions in neutrophils (4000 ± 1200 cells/µL), eosinophils (150 ± 50 cells/µL), basophils (30 ± 10 cells/µL), monocytes (300 ± 100 cells/µL), erythrocytes (4.3 ± 0.6 × 106/µL), and platelets (268 ± 78 × 103/µL). As evaluated in 93 PLWH cases, B cells showed a similar trend (150 ± 50 cells/µL), while the decrease of NK cells was not significant (200 ± 70 cells/µL),. In parallel, we observed a compensatory increase in CD8+ T lymphocytes (850 ± 300 cells/µL). These findings highlight the complex interplay between CD4+ T-cell depletion and both immune and hematologic cells in the context of HIV infection, which emphasizes the need for integrated monitoring to inform targeted interventions and optimize clinical outcomes.