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Background <p>Liver dysfunction, which serves as a critical indicator of advanced liver disease and a driver of mortality in PLWH, is frequently accompanied by perturbations in serum potassium homeostasis. This study aims to investigate the association between serum potassium and liver dysfunction in PLWH, with identifying potential indicative value for risk stratification of hepatic outcomes.</p> Methods <p>A total of 2,725 PLWHs, with 10,718 measurements of serum potassium, were enrolled in this study. Piecewise linear mixed-effect model with smoothing function and Cox regression analysis were used to identify the association of serum potassium with liver dysfunction.</p> Results <p>A U-shaped relationship was identified between serum potassium and liver dysfunction, with a threshold of 4.25 mmol/L. Participants with baseline potassium &gt; 4.25 mmol/L had a 27% (95% CI: 1.04–1.54) higher risk of mild liver dysfunction and a 48% (95% CI: 1.01–2.14) higher risk of severe liver dysfunction, which were confirmed by Kaplan-Meier analyses.</p> Conclusions <p>The study establishes serum potassium concentration as an independent predictor of liver dysfunction in PLWHs, highlighting the importance of potassium monitoring and management for this population.</p>

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Long-term potassium monitoring and dynamics in risk of liver dysfunction among people living with HIV

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月26日

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  • Hong Liu,
  • Jiamin Li,
  • Wenjun Ma,
  • Xia Zhang,
  • Jianfeng Bao,
  • Jing Gao,
  • Yujuan Zhang,
  • Guoxiang Zheng,
  • Dingyan Yan,
  • Yue Zhang,
  • Jinsong Huang,
  • Yinhua Ni,
  • Fang Liu

摘要

Background

Liver dysfunction, which serves as a critical indicator of advanced liver disease and a driver of mortality in PLWH, is frequently accompanied by perturbations in serum potassium homeostasis. This study aims to investigate the association between serum potassium and liver dysfunction in PLWH, with identifying potential indicative value for risk stratification of hepatic outcomes.

Methods

A total of 2,725 PLWHs, with 10,718 measurements of serum potassium, were enrolled in this study. Piecewise linear mixed-effect model with smoothing function and Cox regression analysis were used to identify the association of serum potassium with liver dysfunction.

Results

A U-shaped relationship was identified between serum potassium and liver dysfunction, with a threshold of 4.25 mmol/L. Participants with baseline potassium > 4.25 mmol/L had a 27% (95% CI: 1.04–1.54) higher risk of mild liver dysfunction and a 48% (95% CI: 1.01–2.14) higher risk of severe liver dysfunction, which were confirmed by Kaplan-Meier analyses.

Conclusions

The study establishes serum potassium concentration as an independent predictor of liver dysfunction in PLWHs, highlighting the importance of potassium monitoring and management for this population.