Scholarlink

Introduction <p>Hypoalbuminemia is linked to an earlier onset of acquired immune deficiency syndrome and increased mortality in patients living with HIV infection. Serum albumin is therefore an independent factor for the prediction of disease progression and mortality in People Living With HIV.</p> Methods <p>This was a cross-sectional study conducted at Lira Regional Referral Hospital in northern Uganda that targeted HIV-positive outpatients attending the ART clinic with a sample size of 373 patients. Data were collected through structured interviews and laboratory tests in which the serum albumin concentration, viral load, and CD4 count were measured.</p> Results <p>The prevalence of hypoalbuminemia was 19.6% (73/373). A moderate positive correlation was observed between the serum albumin concentration and the CD4 count (rs = 0.43, <i>p</i> &lt; 0.001). Patients with no formal education [AOR = 2.03, 95%CI = 1.69–2.07, <i>P</i> = 0.03] were 2.03 times more likely to have hypoalbuminemia than those who had a tertiary/university education level. The odds of having hypoalbuminemia [AOR = 2.17, CI = 1.80–3.06, <i>P</i> = 0.02] were 2.17 higher among HIV-infected patients who were naïve ART than among those who were on ART. Additionally, the odds of having hypoalbuminemia [AOR = 2.91, CI = 2.13–3.66, <i>P</i> = 0.01] were 2.91 higher among HIV-infected patients who were in stage four than among those who were in stage 1.</p> Conclusion <p>Hypoalbuminemia prevalence was high in PLWHIV, and a moderate positive correlation was found between the serum albumin level and the CD4 cell count. Lower education level, not being ART, and advanced HIV disease were independently associated with hypoalbuminemia.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Hypoalbuminemia in HIV-infected patients: its determinants and correlation with CD4 count in Northern Uganda

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年9月2日

查看全文
  • Abukar Ali Ahmed,
  • Hanan Asad Hassan,
  • Venance Emmanuel Mswelo,
  • Awil Abdulkadir Abdi,
  • Onyanga Nixson,
  • Hanaa Mohamed Shiekh Omar,
  • Mohamed Jayte,
  • Mohamed Elmalik Musa,
  • Abishir Mohamud Hirsi

摘要

Introduction

Hypoalbuminemia is linked to an earlier onset of acquired immune deficiency syndrome and increased mortality in patients living with HIV infection. Serum albumin is therefore an independent factor for the prediction of disease progression and mortality in People Living With HIV.

Methods

This was a cross-sectional study conducted at Lira Regional Referral Hospital in northern Uganda that targeted HIV-positive outpatients attending the ART clinic with a sample size of 373 patients. Data were collected through structured interviews and laboratory tests in which the serum albumin concentration, viral load, and CD4 count were measured.

Results

The prevalence of hypoalbuminemia was 19.6% (73/373). A moderate positive correlation was observed between the serum albumin concentration and the CD4 count (rs = 0.43, p < 0.001). Patients with no formal education [AOR = 2.03, 95%CI = 1.69–2.07, P = 0.03] were 2.03 times more likely to have hypoalbuminemia than those who had a tertiary/university education level. The odds of having hypoalbuminemia [AOR = 2.17, CI = 1.80–3.06, P = 0.02] were 2.17 higher among HIV-infected patients who were naïve ART than among those who were on ART. Additionally, the odds of having hypoalbuminemia [AOR = 2.91, CI = 2.13–3.66, P = 0.01] were 2.91 higher among HIV-infected patients who were in stage four than among those who were in stage 1.

Conclusion

Hypoalbuminemia prevalence was high in PLWHIV, and a moderate positive correlation was found between the serum albumin level and the CD4 cell count. Lower education level, not being ART, and advanced HIV disease were independently associated with hypoalbuminemia.