Effect of dolutegravir-based versus efavirenz-based antiretroviral therapy on excessive weight gain in adult treatment-naïve HIV patients at Matsanjeni health center, Eswatini: a retrospective cohort study

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2024年1月7日

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Didier M. Mukuna,
Tom Decroo,
Clara M. Nyapokoto

摘要

Background

There is limited data on dolutegravir (DTG)-associated weight gain from settings with a dual burden of HIV and overnutrition.

Methods

In Eswatini (at Matsanjeni), among 156 and 160 adult patients on DTG-based and EFV-based antiretroviral therapy (ART), respectively, we studied excessive weight gain (BMI at 24 months ART greater than baseline and ≥25 kg/m²).

Results

The median BMI increase in DTG-based patients was 1.09 (IQR:-0.28,3.28) kg/m² compared to 0.20 (IQR:-0.85,2.18) kg/m² in EFV-based patients (p value = 0.001). DTG-based ART predicted excessive weight gain (aOR 2.61;95% CI:1.39–4.93).

Conclusion

Practitioners should consider DTG-based regimens as one of the risk factors for overweight/obesity.