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<p>People living with HIV-1 (PLWH) are a population at higher risk for communicable disease and therefore a target group for vaccination. Owing to the success of anti-retroviral therapy, PLWH live longer, but face new challenges related to ageing, which add to their underlying immunodeficiencies. We review here the immune dysregulations occurring with chronic HIV-1 infection and ageing in the era of antiretroviral therapy, focusing on cellular mechanisms that can explain the lower immune response to most vaccines in older treated PLWH, and we discuss potential developments to improve vaccination strategies in this specific population.</p>

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Ageing with HIV-1: immunological challenges for effective vaccination

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月4日

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  • Pauline Saint-Charles,
  • Arnaud M. Didierlaurent,
  • Victor Appay

摘要

People living with HIV-1 (PLWH) are a population at higher risk for communicable disease and therefore a target group for vaccination. Owing to the success of anti-retroviral therapy, PLWH live longer, but face new challenges related to ageing, which add to their underlying immunodeficiencies. We review here the immune dysregulations occurring with chronic HIV-1 infection and ageing in the era of antiretroviral therapy, focusing on cellular mechanisms that can explain the lower immune response to most vaccines in older treated PLWH, and we discuss potential developments to improve vaccination strategies in this specific population.