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<p>Sjögren's syndrome (SS) is an autoimmune disease primarily affecting exocrine glands, characterized by dry mouth and eyes, with an unclear pathogenesis. Recent studies suggest that salivary gland (SG) cell senescence is critical in SS pathogenesis. The senescence mechanism may serve as a critical pathological nexus linking molecular abnormalities to clinical phenotypes. Under assaults from infections, environmental factors, and immune dysregulation, SG cells undergo oxidative stress, telomere shortening, and DNA damage, leading to senescence. Senescent cells lose proliferative capacity and secrete senescence-associated cytokines, triggering inflammation and immune responses that exacerbate disease progression. Elucidating the mechanisms of SG cell senescence may advance our understanding of SS pathogenesis and identify novel therapeutic targets, offering new avenues for SS treatment.</p>

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Salivary gland cell senescence in Sjögren’s syndrome: current research and novel therapeutic directions

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年10月31日

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  • Xiaoyu Tang,
  • Jingjin Hu,
  • Xinying Fan,
  • Haodong Su,
  • Minglu Li,
  • Liyun Zhang,
  • Dan Ma

摘要

Sjögren's syndrome (SS) is an autoimmune disease primarily affecting exocrine glands, characterized by dry mouth and eyes, with an unclear pathogenesis. Recent studies suggest that salivary gland (SG) cell senescence is critical in SS pathogenesis. The senescence mechanism may serve as a critical pathological nexus linking molecular abnormalities to clinical phenotypes. Under assaults from infections, environmental factors, and immune dysregulation, SG cells undergo oxidative stress, telomere shortening, and DNA damage, leading to senescence. Senescent cells lose proliferative capacity and secrete senescence-associated cytokines, triggering inflammation and immune responses that exacerbate disease progression. Elucidating the mechanisms of SG cell senescence may advance our understanding of SS pathogenesis and identify novel therapeutic targets, offering new avenues for SS treatment.