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Objectives <p>To assess the prevalence of endocrine dysfunction in patients with JIA and identify potential contributory factors for growth and sexual development.</p> Methods <p>A prospective observational study was conducted between July 2021 to January 2023, recruited 107 children of JIA fulfilling the revised ILAR classification criteria with disease duration &gt; 6 months, attending Rheumatology department in KGMU, India. Demographic, clinical (anthropometric), and serological (including hormonal) evaluations were assessed at baseline. Growth velocity was recorded after one year. Mann-Whitney U test, chi-square test, and Fisher’s exact t test were applied during statistical analysis.</p> Results <p>107 JIA patients were enrolled with a M: F ratio of 2.06:1 (72 boys &amp; 35 girls) with ERA being the most frequent subtype (51.4%). Mean age was 13 (± 4) years with a disease duration of 33 (± 24) months. Mean glucocorticoid intake was 2.17 (± 5.41) mg/day at baseline. 20.6% children were stunted, 22.4% were underweight and 25.2% had low BMI. Stunted children were more likely to have early onset (<i>p</i> = 0.015) &amp; high GH level (<i>p</i> = 0.013). Underweight children had longer disease (<i>p</i> = 0.047) and more damage (<i>p</i> = 0.006). Children with weight z &lt; -2 have high GH and low IGFBP3. Low BMI group had high disease activity, damage, and poor quality of life &amp; functional state (p = &lt; 0.01). Delayed puberty was noticed only in 2.8% of children. Girls with low Estradiol level had longer exposure to corticosteroids. Slower growth velocity was observed in 22.4% of children without any identifiable cause.</p> Conclusion <p>One third of JIA patients experience growth and pubertal disturbances, primarily due to altered GH-IGF1 axis.</p>

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Endocrine dysfunction in patients with juvenile idiopathic arthritis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年4月24日

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  • Sayan Mukherjee,
  • Abilash Krishnan Vijayakumaran,
  • Mukesh Kumar Maurya,
  • Nishant Gautam Kamble,
  • Ankush PM,
  • Puneet Kumar,
  • Wahid Ali,
  • Mala Kumar,
  • Saurabh Kumar,
  • Pankti Mehta,
  • T. G. Sundaram,
  • Urmila Dhakad

摘要

Objectives

To assess the prevalence of endocrine dysfunction in patients with JIA and identify potential contributory factors for growth and sexual development.

Methods

A prospective observational study was conducted between July 2021 to January 2023, recruited 107 children of JIA fulfilling the revised ILAR classification criteria with disease duration > 6 months, attending Rheumatology department in KGMU, India. Demographic, clinical (anthropometric), and serological (including hormonal) evaluations were assessed at baseline. Growth velocity was recorded after one year. Mann-Whitney U test, chi-square test, and Fisher’s exact t test were applied during statistical analysis.

Results

107 JIA patients were enrolled with a M: F ratio of 2.06:1 (72 boys & 35 girls) with ERA being the most frequent subtype (51.4%). Mean age was 13 (± 4) years with a disease duration of 33 (± 24) months. Mean glucocorticoid intake was 2.17 (± 5.41) mg/day at baseline. 20.6% children were stunted, 22.4% were underweight and 25.2% had low BMI. Stunted children were more likely to have early onset (p = 0.015) & high GH level (p = 0.013). Underweight children had longer disease (p = 0.047) and more damage (p = 0.006). Children with weight z < -2 have high GH and low IGFBP3. Low BMI group had high disease activity, damage, and poor quality of life & functional state (p = < 0.01). Delayed puberty was noticed only in 2.8% of children. Girls with low Estradiol level had longer exposure to corticosteroids. Slower growth velocity was observed in 22.4% of children without any identifiable cause.

Conclusion

One third of JIA patients experience growth and pubertal disturbances, primarily due to altered GH-IGF1 axis.