Scholarlink

Background <p>Cancer remains a major threat to human health worldwide, but with progress in early diagnosis and treatment technology, the progression of cancer has been effectively slowed. Near-infrared (NIR) fluorescent probes are noninvasive imaging tools that show great promise for early tumor detection and intra-operative guidance due to their high sensitivity, deep tissue penetration, and high signal-to-noise ratio.</p> Main body <p>In recent years, the rapid development of NIR fluorescent probes has been driven by a growing understanding of the unique characteristics of the tumor microenvironment. Targeting these features, such as pH, viscosity, polarity, hypoxia, and enzymes, has become a key strategy in the rational design of sensitive small-molecule fluorescent probes for cancer diagnosis and therapy. In this review, we have summarized the recent progress in NIR fluorescent probes for the tumor microenvironment, with an emphasis on their design principles, imaging performance, potential applications, and the challenges faced in clinical translation.</p> Conclusions <p>Despite certain progress in near-infrared fluorescent probes, challenges remain, such as tumor heterogeneity and clinical translation. Future efforts should focus on multi-responsive designs, improved photostability, and multimodal imaging strategies. We hope this review can provide a valuable reference for the development of novel fluorescent probes.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Advances in near-infrared fluorescent probes for the tumor microenvironment

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月14日

查看全文
  • Haodong Hu,
  • Changyue Zhang,
  • Xiaoqi Kong,
  • Ye Chen,
  • Ruijiao Chen

摘要

Background

Cancer remains a major threat to human health worldwide, but with progress in early diagnosis and treatment technology, the progression of cancer has been effectively slowed. Near-infrared (NIR) fluorescent probes are noninvasive imaging tools that show great promise for early tumor detection and intra-operative guidance due to their high sensitivity, deep tissue penetration, and high signal-to-noise ratio.

Main body

In recent years, the rapid development of NIR fluorescent probes has been driven by a growing understanding of the unique characteristics of the tumor microenvironment. Targeting these features, such as pH, viscosity, polarity, hypoxia, and enzymes, has become a key strategy in the rational design of sensitive small-molecule fluorescent probes for cancer diagnosis and therapy. In this review, we have summarized the recent progress in NIR fluorescent probes for the tumor microenvironment, with an emphasis on their design principles, imaging performance, potential applications, and the challenges faced in clinical translation.

Conclusions

Despite certain progress in near-infrared fluorescent probes, challenges remain, such as tumor heterogeneity and clinical translation. Future efforts should focus on multi-responsive designs, improved photostability, and multimodal imaging strategies. We hope this review can provide a valuable reference for the development of novel fluorescent probes.