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<p>N6-methyladenosine (m⁶A) methylation is a predominant form of RNA modification in eukaryotic cells. It exerts profound influence over the processing of mRNA, rRNA and tRNA, thereby playing a critical role in various biological processes, including RNA transcription, splicing, degradation, and translation regulation. The m⁶A methylation significantly affects cell fate and signal transduction pathways by regulating gene expression. Notably, aberrant m⁶A modification is strongly associated with the onset and progression of autoimmune diseases. Emerging evidence indicates that these regulatory factors display disease-specific expression patterns and functional roles, influencing immune-cell differentiation and effector functions, inflammatory responses, and tissue injury. This article provides an overview of recent advances in m⁶A biology in autoimmunity and discusses their implications for diagnosis and therapeutic intervention.</p><p><?noindent??><b>Clinical trial number</b> Not applicable.</p>

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Epigenetic modifier m⁶A methylation: insights into the pathogenesis and therapeutic potential of autoimmune diseases

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月24日

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  • Xue Lv,
  • Wenxin Zhang,
  • Yuefang Liu,
  • Yuelin Hu,
  • Xin Wang,
  • Hongsong Yu

摘要

N6-methyladenosine (m⁶A) methylation is a predominant form of RNA modification in eukaryotic cells. It exerts profound influence over the processing of mRNA, rRNA and tRNA, thereby playing a critical role in various biological processes, including RNA transcription, splicing, degradation, and translation regulation. The m⁶A methylation significantly affects cell fate and signal transduction pathways by regulating gene expression. Notably, aberrant m⁶A modification is strongly associated with the onset and progression of autoimmune diseases. Emerging evidence indicates that these regulatory factors display disease-specific expression patterns and functional roles, influencing immune-cell differentiation and effector functions, inflammatory responses, and tissue injury. This article provides an overview of recent advances in m⁶A biology in autoimmunity and discusses their implications for diagnosis and therapeutic intervention.

Clinical trial number Not applicable.