Scholarlink

Background <p>Lupus nephritis (LN) represents a major complication in systemic lupus erythematosus (SLE). The objective of this study was to evaluate the <i>TRIM8</i> gene and its associated non-coding RNAs (<i>lnc-SSBP2-1:1</i> and <i>hsa-miR-126-5p</i>) as potential non-invasive biomarkers for LN activity.</p> Methods <p>Bioinformatics analyses were initially employed to identify candidate mRNA and associated non-coding RNAs (ncRNAs) implicated in LN. Expression profiles of <i>TRIM8lnc-SSBP2-1:1</i>and <i>hsa-miR-126-5p</i> were validated in blood samples from 40 active LN, 30 inactive LN patients, and 20 healthy individuals via real-time PCR.</p> Results <p><i>TRIM8</i> mRNA and <i>lnc-SSBP2-1:1</i> lncRNA levels were notably upregulated in active LN (<i>p</i> &lt; 0.001), while <i>hsa-miR-126-5p </i>was reduced (<i>p</i> &lt; 0.001). SLEDAI-2K scores correlated positively with <i>TRIM8</i> mRNA and <i>lnc-SSBP2-1:1</i>, and negatively with <i>hsa-miR-126-5p</i>.</p> Conclusions <p>This study highlights <i>TRIM8</i>-associated ncRNA regulatory network as promising biomarkers in LN activωity, with potential clinical impact.</p> Graphical abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

TRIM8-associated non-coding RNA panel as a biomarker for Lupus nephritis activity

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月5日

查看全文
  • Mostafa Abdelnasier Abd Elgawad,
  • Howayda Abdelhamid El Shinnawy,
  • Sanaa Eissa,
  • Nouran Abdelfattah Sayed Ali,
  • Maha Abdelmoneim Behairy,
  • Cherry Reda Kamel,
  • Marwa Mostafa Kamel

摘要

Background

Lupus nephritis (LN) represents a major complication in systemic lupus erythematosus (SLE). The objective of this study was to evaluate the TRIM8 gene and its associated non-coding RNAs (lnc-SSBP2-1:1 and hsa-miR-126-5p) as potential non-invasive biomarkers for LN activity.

Methods

Bioinformatics analyses were initially employed to identify candidate mRNA and associated non-coding RNAs (ncRNAs) implicated in LN. Expression profiles of TRIM8lnc-SSBP2-1:1and hsa-miR-126-5p were validated in blood samples from 40 active LN, 30 inactive LN patients, and 20 healthy individuals via real-time PCR.

Results

TRIM8 mRNA and lnc-SSBP2-1:1 lncRNA levels were notably upregulated in active LN (p < 0.001), while hsa-miR-126-5p was reduced (p < 0.001). SLEDAI-2K scores correlated positively with TRIM8 mRNA and lnc-SSBP2-1:1, and negatively with hsa-miR-126-5p.

Conclusions

This study highlights TRIM8-associated ncRNA regulatory network as promising biomarkers in LN activωity, with potential clinical impact.

Graphical abstract