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<p>Neutrophils, which represent about 50–70% of circulating leukocytes in humans, have been viewed as short-lived effector cells of the innate immune system with a primary role in the clearance of pathogens and taking part in inflammatory processes. More recent evidence shows that neutrophils make up a significant portion of the inflammatory cell infiltration in many types of cancer, including non-small cell lung cancer (NSCLC). These tumor-associated neutrophils (TANs) can be divided into protumorigenic and antitumorigenic phenotypes. The biological features and functions of these TANs are under the influence of the tumor microenvironment. TANs also play a role in determining the responsiveness of NSCLC to immunotherapies targeting the programmed cell death-1 (PD-1)/programmed death ligand 1 (PD-L1) axis. This review aimed to summarize recent findings regarding the role of TANs in NSCLC progression and PD-1/PD-L1 targeted immunotherapy.</p>

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Neutrophils in non-small cell lung cancer and immunotherapy with PD-1/PD-L1 inhibitors

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月18日

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  • Shaojie Hu,
  • Chenxi Yan,
  • Yitao Tian,
  • Wei Sun

摘要

Neutrophils, which represent about 50–70% of circulating leukocytes in humans, have been viewed as short-lived effector cells of the innate immune system with a primary role in the clearance of pathogens and taking part in inflammatory processes. More recent evidence shows that neutrophils make up a significant portion of the inflammatory cell infiltration in many types of cancer, including non-small cell lung cancer (NSCLC). These tumor-associated neutrophils (TANs) can be divided into protumorigenic and antitumorigenic phenotypes. The biological features and functions of these TANs are under the influence of the tumor microenvironment. TANs also play a role in determining the responsiveness of NSCLC to immunotherapies targeting the programmed cell death-1 (PD-1)/programmed death ligand 1 (PD-L1) axis. This review aimed to summarize recent findings regarding the role of TANs in NSCLC progression and PD-1/PD-L1 targeted immunotherapy.