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<p>We are writing to commend the recent article by Zhuang et al. titled “SIGMAR1 screened by a GPCR-related classifier regulates endoplasmic reticulum stress in bladder cancer,” published in the Journal of Translational Medicine. This is a highly innovative and clinically significant article that seamlessly integrates bioinformatics and functional analysis to identify SIGMAR1 as a key regulator of endoplasmic reticulum (ER) stress in bladder cancer (BC). Additionally, it establishes a GPCR-tumor microenvironment (TME) classification system combining 15 GPCRs and five immune cell types, offering a novel perspective on traditional clinical treatment research directions. We offer some constructive suggestions here, hoping that our ideas can contribute to a more comprehensive understanding of the mechanisms of SIGMAR1 in BC progression. We sincerely appreciate the time and effort you have invested in this research.</p>

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Letter to editor: SIGMAR1 screened by a GPCR-related classifier regulates endoplasmic reticulum stress in bladder cancer

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年8月6日

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  • Xiaoman Zhang,
  • Yipeng Cong,
  • Xu Zheng,
  • Guangzhen Wu

摘要

We are writing to commend the recent article by Zhuang et al. titled “SIGMAR1 screened by a GPCR-related classifier regulates endoplasmic reticulum stress in bladder cancer,” published in the Journal of Translational Medicine. This is a highly innovative and clinically significant article that seamlessly integrates bioinformatics and functional analysis to identify SIGMAR1 as a key regulator of endoplasmic reticulum (ER) stress in bladder cancer (BC). Additionally, it establishes a GPCR-tumor microenvironment (TME) classification system combining 15 GPCRs and five immune cell types, offering a novel perspective on traditional clinical treatment research directions. We offer some constructive suggestions here, hoping that our ideas can contribute to a more comprehensive understanding of the mechanisms of SIGMAR1 in BC progression. We sincerely appreciate the time and effort you have invested in this research.