Scholarlink

<p>S-palmitoylation is a dynamic, reversible lipid modification that plays a crucial role in the regulation of various types of cell death. However, systematic insights into how S-palmitoylation modifications integrate and mediate crosstalk among diverse cell death pathways, including apoptosis, necroptosis, pyroptosis, ferroptosis, and cuproptosis, to ultimately determine cell fate remain elusive. We propose the concept of the “palmitoylation code,” which posits that S-palmitoylation affects substrate function and signaling pathways through site specificity, kinetic dynamics, and spatial distribution, ultimately regulating the cell’s decision between survival and death. This review describes the regulatory principles of this code in major cell death pathways and provides a comprehensive overview of palmitoylation-targeting strategies and pharmacological inhibitors through an examination of how targeting the “palmitoylation code” can modulate cell fate transitions.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

From lipid modification to cell death: the diverse roles of S-palmitoylation in cell fate decisions

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年4月11日

查看全文
  • Yue Zhu,
  • Chunyu Ma,
  • Liping Zhong,
  • Tingting Wang,
  • Weiwei Liu,
  • Zishu Wang

摘要

S-palmitoylation is a dynamic, reversible lipid modification that plays a crucial role in the regulation of various types of cell death. However, systematic insights into how S-palmitoylation modifications integrate and mediate crosstalk among diverse cell death pathways, including apoptosis, necroptosis, pyroptosis, ferroptosis, and cuproptosis, to ultimately determine cell fate remain elusive. We propose the concept of the “palmitoylation code,” which posits that S-palmitoylation affects substrate function and signaling pathways through site specificity, kinetic dynamics, and spatial distribution, ultimately regulating the cell’s decision between survival and death. This review describes the regulatory principles of this code in major cell death pathways and provides a comprehensive overview of palmitoylation-targeting strategies and pharmacological inhibitors through an examination of how targeting the “palmitoylation code” can modulate cell fate transitions.