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<p>The very low-density lipoprotein receptor (VLDLR), a member of the low-density lipoprotein receptor superfamily, mediates the endocytosis of very-low-density lipoproteins and participates in a wide range of physiological and pathological processes, including neurodevelopment, viral infection, and angiogenesis. Recent studies have shown that VLDLR facilitates alphavirus entry and exhibits a distinct spatiotemporal expression pattern in the liver. This review summarizes the structural features of VLDLR and systematically evaluates its multifaceted roles: mediating viral entry; promoting hepatic VLDL uptake to lower circulating lipid levels; transducing Reelin signaling for cortical and cerebellar lamination; suppressing pathological retinal angiogenesis; and modulating cancer progression. These insights provide a comprehensive overview of the versatile functions of VLDLR.</p>

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VLDLR: A Multifunctional receptor in diverse pathophysiological processes

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月26日

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  • Xinyu Wang,
  • Yan Chen,
  • Jinmei Wei,
  • Yanling Li,
  • Juan Xu,
  • Tao Dai,
  • Ning Tang,
  • Chen Han,
  • Yanhong Zhou

摘要

The very low-density lipoprotein receptor (VLDLR), a member of the low-density lipoprotein receptor superfamily, mediates the endocytosis of very-low-density lipoproteins and participates in a wide range of physiological and pathological processes, including neurodevelopment, viral infection, and angiogenesis. Recent studies have shown that VLDLR facilitates alphavirus entry and exhibits a distinct spatiotemporal expression pattern in the liver. This review summarizes the structural features of VLDLR and systematically evaluates its multifaceted roles: mediating viral entry; promoting hepatic VLDL uptake to lower circulating lipid levels; transducing Reelin signaling for cortical and cerebellar lamination; suppressing pathological retinal angiogenesis; and modulating cancer progression. These insights provide a comprehensive overview of the versatile functions of VLDLR.