Scholarlink

Abstract <p>Apoptotic cells release a highly heterogeneous population of extracellular vesicles, which can be categorized into apoptotic bodies, apoptotic microvesicles, and apoptotic exosomes. These apoptotic vesicles (apoVs) not only inherit materials from their parental cells but also encapsulate apoptosis-related factors, thereby playing multifaceted roles in signal transduction, homeostatic regulation, and the tumor microenvironment. This review highlights recent advances in the cell biology of apoptotic extracellular vesicles, with a focus on the unique characteristics of tumor-derived ApoVs and their mechanisms of interaction in immune evasion, angiogenesis, and the modulation of the tumor microenvironment. Additionally, the potential of ApoEVs as biomarkers for tumor diagnostics is explored. In the realm of tumor therapy, engineered and modified ApoEVs have emerged as promising drug delivery vehicles and vaccine carriers, enabling targeted delivery of therapeutic agents and showing significant potential in antitumor immunization strategies.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Apoptotic vesicles in cancer: research progress in physiology and therapy

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年2月27日

查看全文
  • Jingyu Dai,
  • Yibing Liu,
  • Tao Tang,
  • Mingsheng Tang,
  • Jun Chen,
  • Hailan Wang,
  • Xi Liu

摘要

Abstract

Apoptotic cells release a highly heterogeneous population of extracellular vesicles, which can be categorized into apoptotic bodies, apoptotic microvesicles, and apoptotic exosomes. These apoptotic vesicles (apoVs) not only inherit materials from their parental cells but also encapsulate apoptosis-related factors, thereby playing multifaceted roles in signal transduction, homeostatic regulation, and the tumor microenvironment. This review highlights recent advances in the cell biology of apoptotic extracellular vesicles, with a focus on the unique characteristics of tumor-derived ApoVs and their mechanisms of interaction in immune evasion, angiogenesis, and the modulation of the tumor microenvironment. Additionally, the potential of ApoEVs as biomarkers for tumor diagnostics is explored. In the realm of tumor therapy, engineered and modified ApoEVs have emerged as promising drug delivery vehicles and vaccine carriers, enabling targeted delivery of therapeutic agents and showing significant potential in antitumor immunization strategies.