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<p>Aflatoxin B1 (AFB1) is a potent mycotoxin that impairs reproductive health, yet its impact on oocyte metabolism remains unclear. Our study aimed to characterize the metabolic profile of mouse oocytes exposed to AFB1.Using a murine model of chronic AFB1 exposure, we performed integrated metabolomic and proteomic analyses of oocytes. AFB1 exposure induced profound metabolic reprogramming, characterized by excessive activation of fatty acid β-oxidation (FAO) and one-carbon metabolism, and suppressed nucleotide metabolism. Functional assays further demonstrated that exogenous taurine supplementation improved quality of AFB1-exposed oocytes, specifically, alleviating meiotic defects and metabolic dysfunction. Collectively, these findings provide novel mechanistic insight into AFB1-induced metabolic perturbations in oocytes and highlight taurine as a promising intervention to mitigate mycotoxin-associated reproductive toxicity.</p>

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Integrated metabolomic and proteomic analyses reveal global reprogramming of oocyte metabolism following AFB1 exposure

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月5日

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  • Yue Xiong,
  • Ming Gao,
  • Yixin Ma,
  • Yueshuai Guo,
  • Xuejiang Guo,
  • Qiang Wang,
  • Minjian Chen,
  • Ling Gu

摘要

Aflatoxin B1 (AFB1) is a potent mycotoxin that impairs reproductive health, yet its impact on oocyte metabolism remains unclear. Our study aimed to characterize the metabolic profile of mouse oocytes exposed to AFB1.Using a murine model of chronic AFB1 exposure, we performed integrated metabolomic and proteomic analyses of oocytes. AFB1 exposure induced profound metabolic reprogramming, characterized by excessive activation of fatty acid β-oxidation (FAO) and one-carbon metabolism, and suppressed nucleotide metabolism. Functional assays further demonstrated that exogenous taurine supplementation improved quality of AFB1-exposed oocytes, specifically, alleviating meiotic defects and metabolic dysfunction. Collectively, these findings provide novel mechanistic insight into AFB1-induced metabolic perturbations in oocytes and highlight taurine as a promising intervention to mitigate mycotoxin-associated reproductive toxicity.