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<p>Regulatory proteins, including those involved in signal transduction, invariably have intrinsic disorder. Enzymes, on the other hand, rely on unique structures for their pre-formed active sites to carry out catalysis. Disorder-promoting amino acids are shown to be non-essential amino acids, for which there are minimum biosynthetic costs. Therefore, disorder costs less to cells.</p>

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The cellular economy while crafting regulatory processes relies on protein intrinsic disorder: how and why precision comes at a cost in protein structure

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月21日

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  • Munishwar Nath Gupta,
  • Vladimir N. Uversky

摘要

Regulatory proteins, including those involved in signal transduction, invariably have intrinsic disorder. Enzymes, on the other hand, rely on unique structures for their pre-formed active sites to carry out catalysis. Disorder-promoting amino acids are shown to be non-essential amino acids, for which there are minimum biosynthetic costs. Therefore, disorder costs less to cells.