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<p>A 41 year old female with congenital thrombotic thrombocytopenic purpura (cTTP) underwent a total hip arthroplasty under prophylaxis with recombinant ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin motifs 13). The procedure was performed without complications 12&#xa0;h after the last injection. Postoperative ADAMTS13 activity levels showed a more rapid decrease in activity and in the individual apparent half-life due to increased consumption of the recombinant protease that could safely be managed by an intensified dosing regimen.</p>

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Reduced half-life of recombinant ADAMTS13 in a patient with cTTP undergoing total hip arthroplasty

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月27日

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  • Maria Weise,
  • Thomas Siegemund,
  • Tristan Klöter,
  • Maren Keller,
  • Sirak Petros,
  • Christian Pfrepper

摘要

A 41 year old female with congenital thrombotic thrombocytopenic purpura (cTTP) underwent a total hip arthroplasty under prophylaxis with recombinant ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin motifs 13). The procedure was performed without complications 12 h after the last injection. Postoperative ADAMTS13 activity levels showed a more rapid decrease in activity and in the individual apparent half-life due to increased consumption of the recombinant protease that could safely be managed by an intensified dosing regimen.